%0 Generic
%A García Esteban, María Teresa
%A Blázquez Ferrer, María Amparo
%A Ferrandiz Avellano, María josé
%A Sanz Ferrando, María Jesús
%A Silva Martín,  Noella
%A Hermoso Domínguez, Juan Antonio
%T New antibiotics against DNA. Topoisomerase I of S. pneumoniae
%D 2010
%U https://hdl.handle.net/20.500.14352/130565
%X S. pneumoniae is the main ethological agent of community-acquired pneumonia. Pneumococcal DNA topoisomerase complement, that control its DNA topology, consists of two type II enzymes (DNA gyrase and DNA topoisomerase IV) and a single type I enzyme (DNA topoisomerase I, TopA). While fluoroquinolone antibiotics target the type II topoisomerases, no antibiotics against TopA has yet been reported. Antibiotic resistance is a serious clinical problem in all the world. An increase in resistance to fluoroquinolones in S. pneumoniae it is not unexpected. Therefore, it is necessary to look for new antibiotics against new targets
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