RT Conference Proceedings
T1 New antibiotics against DNA. Topoisomerase I of S. pneumoniae
A1 García Esteban, María Teresa
A1 Blázquez Ferrer, María Amparo
A1 Ferrandiz Avellano, María josé
A1 Sanz Ferrando, María Jesús
A1 Silva Martín, Noella
A1 Hermoso Domínguez, Juan Antonio
AB S. pneumoniae is the main ethological agent of community-acquired pneumonia. Pneumococcal DNA topoisomerase complement, that control its DNA topology, consists of two type II enzymes (DNA gyrase and DNA topoisomerase IV) and a single type I enzyme (DNA topoisomerase I, TopA). While fluoroquinolone antibiotics target the type II topoisomerases, no antibiotics against TopA has yet been reported. Antibiotic resistance is a serious clinical problem in all the world. An increase in resistance to fluoroquinolones in S. pneumoniae it is not unexpected. Therefore, it is necessary to look for new antibiotics against new targets
YR 2010
FD 2010-01
LK https://hdl.handle.net/20.500.14352/130565
UL https://hdl.handle.net/20.500.14352/130565
LA spa
DS Docta Complutense
RD 24 ene 2026