RT Journal Article
T1 Source Analysis of Spontaneous Magnetoencephalograpic Activity in Healthy Aging and Mild Cognitive Impairment: Influence of Apolipoprotein E Polymorphism
A1 Fernandez Lucas, Alberto
A1 Cuesta Prieto, Pablo
A1 Barabash Bustelo, Ana
A1 Aurtenetxe, Sara
A1 Garcés, Pilar
A1 López, María Eugenia
A1 Bajo Bretón, Ricardo
A1 Llanero Luque, Marcos
A1 Ancín, Inés
A1 Cabranes Díaz, José Antonio
A1 Marcos Dolado, Alberto
A1 Sancho Ruiz, Miguel
A1 Nakamura, Akinori
A1 Maestu Unturbe, Fernando
A1 Fernández Lucas, Alberto Amable
AB The apolipoprotein E (APOE) epsilon 4 allele is a genetic risk factor for the development of late-onset Alzheimer's disease (AD), which affects cholinergic system functioning. The association between reduced cholinergic levels and increase of magnetoencephalographic (MEG) low-frequency has been used to explain spectral changes found in AD patients. However, the investigation in predementia stages is scarce. We obtained MEG recordings from 25 aged controls and 36 mild cognitive impairment (MCI) patients during a resting-state condition. According to their APOE genotype, MCIs and controls were subdivided in carriers and non-carriers of the 4 allele. Sources of spectral variations in these groups were calculated through beamforming. MCI patients exhibited a significant increase of relative power within the low-frequency domain, accompanied by a power decrease within the high-frequency range. APOE epsilon 4 carriers showed an increased relative power in the 4.5-6.5 Hz frequency range over frontal lobes. The power increase observed in controls carrying epsilon 4 was significantly higher as compared with MCI non-carriers, while MCI carriers exhibited the highest relative power within the 4.5-6.5 Hz range. Higher power values within the low-frequency ranges correlated with a poorer cognitive performance in MCIs and controls. Our investigation demonstrates thatAPOE epsilon 4 affects resting-state activity to an extent that makes it more proximate to the pattern observed in early stages of AD. Therefore, a combination of genetic and neurophysiological information might help to detect MCI patients at higher risk of conversion to AD, and asymptomatic subjects at higher risk of developing a manifest cognitive deterioration.
PB IOS Press
SN 1875-8908
SN 1387-2877
YR 2014
FD 2014-10-30
LK https://hdl.handle.net/20.500.14352/116481
UL https://hdl.handle.net/20.500.14352/116481
LA eng
NO Cuesta P, Barabash A, Aurtenetxe S, Garcés P, López ME, Bajo R, et al. Source Analysis of Spontaneous Magnetoencephalograpic Activity in Healthy Aging and Mild Cognitive Impairment: Influence of Apolipoprotein E Polymorphism. JAD 2014;43:259–73. https://doi.org/10.3233/JAD-140633
NO Ministerio de Ciencia y Economía
NO Instituto de Salud Carlos III
DS Docta Complutense
RD 15 dic 2025