%0 Journal Article
%A Gómez-Carpintero Jiménez, Jorge
%A Sánchez Cebrián, Juan Domingo
%A González Matilla, Juan Francisco
%A Menéndez Ramos, José Carlos
%T Mechanochemical Synthesis of Primary Amides
%D 2021
%@ 0022-3263
%U https://hdl.handle.net/20.500.14352/4599
%X Ball milling of aromatic, heteroaromatic, vinylic, and aliphatic esters with ethanol and calcium nitride afforded the corresponding primary amides in a transformation that was compatible with a variety of functional groups and maintained the integrity of a stereocenter α to carbonyl. This methodology was applied to α-amino esters and N-BOC dipeptide esters and also to the synthesis of rufinamide, an antiepileptic drug.
%~