RT Journal Article
T1 Mechanochemical Synthesis of Primary Amides
A1 Gómez-Carpintero Jiménez, Jorge
A1 Sánchez Cebrián, Juan Domingo
A1 González Matilla, Juan Francisco
A1 Menéndez Ramos, José Carlos
AB Ball milling of aromatic, heteroaromatic, vinylic, and aliphatic esters with ethanol and calcium nitride afforded the corresponding primary amides in a transformation that was compatible with a variety of functional groups and maintained the integrity of a stereocenter α to carbonyl. This methodology was applied to α-amino esters and N-BOC dipeptide esters and also to the synthesis of rufinamide, an antiepileptic drug.
PB ACS Publications
SN 0022-3263
YR 2021
FD 2021-10-01
LK https://hdl.handle.net/20.500.14352/4599
UL https://hdl.handle.net/20.500.14352/4599
LA eng
NO Gómez-Carpintero Jiménez, J., Sánchez Cebrián, J. D., González Matilla, J. F. & Menéndez Ramos, J. C. «Mechanochemical Synthesis of Primary Amides». The Journal of Organic Chemistry, vol. 86, n.o 20, octubre de 2021, pp. 14232-37. DOI.org (Crossref), https://doi.org/10.1021/acs.joc.1c02350.
NO CRUE-CSIC (Acuerdos Transformativos 2021)
NO Ministerio de Ciencia, Innovación y Universidades (España)
NO Cooperación Europea en el Campo de la Investigación Científica y Técnica
DS Docta Complutense
RD 28 abr 2025