RT Journal Article
T1 Genomic organization of a novel glycosylphosphatidylinositol MAM gene expressed in human tissues and tumors
A1 González Quevedo, Rosa
A1 Morán, Alberto
A1 Cruces, Jesús
A1 Juan Chocano, María Del Carmen De
A1 Iniesta Serrano, María Pilar
A1 Sánchez Pernaute, Andrés
A1 Torres García, Antonio José
A1 Balibrea Cantero, José Luis
A1 Díaz-Rubio García, Eduardo
A1 Benito De Las Heras, Manuel R.
AB We report the genomic organization of a novel human gene mapped to chromosome 6p21, encoding a putative glycosylphosphatidylinositol (GPI) anchored protein containing a MAM (meprin, A5 antigen, protein tyrosine phosphatase mu) domain, that we have termed as GPIM (GPI and MAM) protein. GPIM gene consists of an 8.9 kb transcript composed of 17 coding exons spanning about 65.5 kb of genomic DNA. The deduced polypeptide consists of 955 amino acids and exhibits structural features found in different types of cell adhesion molecules (CAMs), such as the presence of immunoglobulin domains, the presence of a MAM domain or the capacity to anchor to the cell membrane by a GPI motif. Expression analysis in normal human tissues revealed that this gene is expressed as a 5 kb and 9.5 kb mRNA. Furthermore, the smaller transcript is highly expressed in some human cancer cell lines, as well as in different primary tumors (lung, colon, uterus, stomach and breast). Interestingly, the gene was higher expressed in several tumor tissues analysed as compared to their corresponding normal tissues. Thus, GPIM is a novel gene codifying a protein with structural features characteristics of some CAMs, which might be involved in the tumor progression.
PB Spinger nature
SN 0950-9232
YR 2002
FD 2002-05-02
LK https://hdl.handle.net/20.500.14352/116834
UL https://hdl.handle.net/20.500.14352/116834
LA eng
NO De Juan C, Iniesta P, González-Quevedo R, Morán A, Sánchez-Pernaute A, Torres AJ, Balibrea JL, Díaz-Rubio E, Cruces J, Benito M. Genomic organization of a novel glycosylphosphatidylinositol MAM gene expressed in human tissues and tumors. Oncogene. 2002 May 2;21(19):3089-94. doi: 10.1038/sj.onc.1205383.
DS Docta Complutense
RD 10 abr 2025