RT Journal Article T1 A Red-Berry mixture as a Nutraceutical: detailed compositionand neuronal protective effect A1 Carballeda-Sangiao, Noelia A1 Chamorro Francisco, Susana A1 Pascual-Teresa, Sonia de AB Recommendations towards increased consumption of fresh fruit and vegetables are well supported by epidemiological and clinical trials. However, in some specific cases, it is difficult to follow these recommendations and the use of nutraceuticals or, in the present work, a freezedried fruits mixture can be recommended in order to afford the optimal consumption of dietary polyphenols naturally present in fruits and vegetables. In this work we have carefully characterized a red-berry mixture in terms of polyphenol composition, encountering mainly anthocyanins, which account for a total of 2.8 mg/g as cyanidin-3-glucoside equivalents. Additionally, we have assayed the red-berry blend in a cell model of neurological damage by differentiating the cells and measuring the effect of red-berry polyphenols on cell viability and redox state by flow cytometry. The berry-fruit extract showed an inhibitory effect on differentiated SH-SY5Y ROS formation at a concentration as low as 250 µg/mL (33% inhibition). The results show the potential of this berry-fruit blend for its nutraceutical use in the prevention of the neurodegeneration associated with age or environmental agents. PB MDPI SN 1420-3049, ESSN: 1420-3049 YR 2021 FD 2021-05-27 LK https://hdl.handle.net/20.500.14352/8668 UL https://hdl.handle.net/20.500.14352/8668 LA eng NO Ministerio de Ciencia e Innovación (MICINN) DS Docta Complutense RD 2 may 2024