RT Journal Article
T1 A Microbial Strategy to Multiply in Macrophages: The Pregnant Pause
A1 Swanson, Michele S.
A1 Fernández Moreira, Esteban
AB Humans live in harmony with much of the microbial world, thanks to a sophisticated immune system. As the first line of defense, macrophages engulf, digest,and display foreign material, then recruit specialists to eliminate potential threats. Yet infiltrators exist: certain fungi, viruses, parasites, and bacteria thrive withinsentinel macrophages. By scrutinizing the life styles of these shrewd microbes, we can deduce how macrophages routinely mount an effective immune response.The bimorphic life cycles of three pathogens have dramatic consequences for phagosome traffic. In the transmissible state, Leishmania spp., Coxiella burnetii,and Legionella pneumophila block phagosome maturation; after a pregnant pause, replicative forms emerge and thrive in lysosomes.
PB Wiley
SN 1398-9219
YR 2002
FD 2002-03-18
LK https://hdl.handle.net/20.500.14352/125159
UL https://hdl.handle.net/20.500.14352/125159
LA eng
NO Swanson MS, Fernandez-Moreira E. A microbial strategy to multiply in macrophages: the pregnant pause. Traffic. 2002 Mar;3(3):170-7. doi: 10.1034/j.1600-0854.2002.030302.x. Erratum in: Traffic. 2002 Jul;3(7):512.. Fernandez-Moreia Esteban [corrected to Fernandez-Moreira Esteban].
DS Docta Complutense
RD 25 feb 2026