RT Journal Article
T1 Antibacterial, Trichomonacidal, and Cytotoxic Activities of Pleopeltis crassinervata Extracts
A1 Anacleto-Santos, Jhony
A1 Vega-Ávila, Elisa
A1 Pacheco, Leticia
A1 Lacueva-Arnedo, Manuel
A1 Gómez Barrio, Alicia
A1 Ibáñez Escribano, Alexandra
A1 López-Pérez, Teresa de Jesús
A1 Casarrubias-Tabarez, Brenda
A1 Calzada, Fernando
A1 López-Camacho, Perla Yolanda
A1 Rivera-Fernández, Norma
AB Pleopeltis crassinervata is a fern documented in ethnobotanical records for its use in Mexican traditional medicine to treat gastric disorders and mouth ulcers. Consequently, conducting biological and pharmacological assays is crucial to validate the therapeutic efficacy of this plant within the context of traditional medicine. In the present study, we investigated the biological activity of extracts and fractions obtained from P. crassinervata organs against bacteria (Salmonella typhimurium, Salmonella typhi, Staphylococcus aureus, Proteus mirabilis, Shigella flexneri, Bacillus subtilis, Escherichia coli) and Trichomonas vaginalis using in vitro models. The precipitate fraction obtained from the frond methanolic extract showed significant antibacterial activity (minimal inhibitory concentration [MIC] 120 µg/mL) against the Staphylococcus aureus strain and was effective against both Gram-positive and Gram-negative bacteria. The hexane fraction also obtained from frond methanolic extract, showed a trichomonacidal effect with an IC50 of 82.8 μg/mL and a low cytotoxic effect. Hsf6 exhibited the highest activity against T. vaginalis, and the GC-MS analysis revealed that the predominant compound was 16-pregnenolone. The remaining identified compounds were primarily terpene-type compounds.
PB MDPI
SN 1999-4923
YR 2024
FD 2024-05-07
LK https://hdl.handle.net/20.500.14352/104299
UL https://hdl.handle.net/20.500.14352/104299
LA eng
NO Consejo Nacional de Humanidades, Ciencia y Tecnología (México)
NO Universidad Nacional Autónoma de México
DS Docta Complutense
RD 17 abr 2025