RT Journal Article
T1 Evaluation of a Toothpaste Containing Cetylpyridinium Chloride and Cymenol—A Randomized Clinical Trial
A1 Vasconcelos, Viviane
A1 Laciar, Florencia
A1 Matesanz Pérez, Paula
A1 Iniesta Albentosa, Margarita Isabel
A1 Alonso Álvarez, Bettina María
A1 Roldán, Silvia
A1 Serrano, Jorge
A1 Furmanczyk, Marta
A1 Bustos, Javier
A1 Trullas, Carles
A1 Jourdan, Eric
A1 Sanz Alonso, Mariano
A1 Herrera González, David
AB The primary objective was to assess the safety of a new toothpaste formulation containing cetylpyridinium chloride (CPC) and cymenol as active agents. In addition, clinical efficacy and patient perception were evaluated. A 6-week randomized clinical trial was designed and patients were randomly allocated to use a test or control dentifrice. Adverse effects were assessed at 3- and 6-week follow-up visits, together with the following clinical parameters: Turesky plaque index (PlI), bleeding on marginal probing (BOMP), bleeding on probing (BOP) and Gründemann modification of the stain index (GMSI). Patient-reported outcome measures (PROMs) were also evaluated. A total of 60 patients were randomized and 55 were finally included in the analysis (test, 29; control, 26). Both toothpastes were safe and well tolerated by the patients. Statistically significant differences between test and control groups were observed for BOP changes between baseline week 6 (p = 0.031) and lower levels of plaque were registered in the test group at the 3- and 6-week visits (p < 0.05). No differences were observed for staining or PROMs. The use of a toothpaste containing CPC and cymenol was safe and not associated with any adverse effects. Significantly better clinical results were observed for the test group in terms of PlI levels and BOP reductions.
PB MDPI
YR 2023
FD 2023-12-21
LK https://hdl.handle.net/20.500.14352/112221
UL https://hdl.handle.net/20.500.14352/112221
LA eng
NO Vasconcelos V., Laciar F., Matesanz P., Iniesta M., Alonso B., Roldán S., Serrano J., Furmanczyk M., Bustos J., Trullas C., Jourdan E., Sanz, M., Herrera, D. Evaluation of a Toothpaste Containing Cetylpyridinium Chloride and Cymenol—A Randomized Clinical Trial. Applied Sciences. 2024; 14(1):105. https://doi.org/10.3390/app14010105
NO 2023 Descuento MDPI
DS Docta Complutense
RD 5 abr 2025