RT Journal Article
T1 Synergy of Regenerative Periodontal Surgery and Orthodontics Improves Quality of Life of Patients with Stage IV Periodontitis: 24-Month Outcomes of a Multicenter RCT
A1 Jepsen, Karin
A1 Tietmann, Christina
A1 Martín Álvaro, María Concepción
A1 Kutschera, Eric
A1 Jäger, Andreas
A1 Wüllenweber, Peter
A1 Gaveglio, Lorena
A1 Cardaropoli, Daniele
A1 Sanz Sánchez, Ignacio
A1 Fimmers, Rolf
A1 Jepsen, Søren
AB In stage IV periodontitis patients with pathologic tooth migration (PTM), interdisciplinary treatment includes regenerative periodontal surgery (RPS) with an application of biomaterials and orthodontic therapy (OT) to restore function, esthetics and thereby quality of life (QoL). In a 24-month randomized trial we explored the synergy between regenerative medicine and biomechanical force application. The following methods were used: Forty-three patients had been randomized to a combined treatment comprising RPS and subsequent OT starting either 4 weeks (early OT) or 6 months (late OT) post-operatively. Clinical periodontal parameters and oral health-related QoL (GOHAI) were recorded up to 24 months. We obtained the following results: Mean clinical attachment gain (∆CAL ± SD) was significantly higher with early OT (5.96 ± 2.1 mm) versus late OT (4.65 ± 1.76 mm) (p = 0.034). Pocket closure (PPD ≤ 4 mm) was obtained in 91% of defects with early OT compared to 90% with late OT. GOHAI-scores decreased significantly from 26.1 ± 7.5 to 9.6 ± 4.7 (early OT) and 25.1 ± 7.1 to 12.7 ± 5.6 (late OT). Inconclusion, teeth severely compromised by intrabony defects and PTM can be treated successfully by RPS followed by early OT with the advantage of an overall reduced treatment time. As a result of the combined periodontal-orthodontic therapy, the oral health-related QoL of patients was significantly improved. Early stimulation of wound healing with orthodontic forces had a favorable impact on the outcomes of regenerative periodontal surgery.
PB MDPI
YR 2023
FD 2023-06-07
LK https://hdl.handle.net/20.500.14352/104961
UL https://hdl.handle.net/20.500.14352/104961
LA eng
NO Jepsen K, Tietmann C, Martin C, Kutschera E, Jäger A, Wüllenweber P, et al. Synergy of Regenerative Periodontal Surgery and Orthodontics Improves Quality of Life of Patients with Stage IV Periodontitis: 24-Month Outcomes of a Multicenter RCT. Bioengineering 2023;10:695. https://doi.org/10.3390/bioengineering10060695.
NO 2023 Descuento MDPI
NO University of Bonn (Germany)
DS Docta Complutense
RD 10 abr 2025