RT Journal Article
T1 Gold-Catalyzed Cyclizations of Alkynol-Based Compounds: Synthesis of Natural Products and Derivatives
A1 Alcaide, Benito
A1 Almendros, Pedro
A1 Alonso Gómez, José Miguel
AB The last decade has witnessed dramatic growth in the number of reactions catalyzed by gold complexes because of their powerful soft Lewis acid nature. In particular, the gold-catalyzed activation of propargylic compounds has progressively emerged in recent years. Some of these gold-catalyzed reactions in alkynes have been optimized and show significant utility in organic synthesis. Thus, apart from significant methodology work, in the meantime gold-catalyzed cyclizations in alkynol derivatives have become an efficient tool in total synthesis. However, there is a lack of specific review articles covering the joined importance of both gold salts and alkynol-based compounds for the synthesis of natural products and derivatives. The aim of this Review is to survey the chemistry of alkynol derivatives under gold-catalyzed cyclization conditions and its utility in total synthesis, concentrating on the advances that have been made in the last decade, and in particular in the last quinquennium.
PB MDPI
SN 1420-3049
YR 2011
FD 2011-09-13
LK https://hdl.handle.net/20.500.14352/43249
UL https://hdl.handle.net/20.500.14352/43249
LA eng
NO Ministerio de Ciencia e Innovación (MICIIN)
NO Comunidad de Madrid
NO Banco Santander/Universidad Complutense de Madrid
DS Docta Complutense
RD 6 oct 2024