RT Journal Article
T1 S‐nitrosation and neuronal plasticity
A1 Santos, A. I.
A1 Martínez Ruiz, Antonio
A1 Araújo, I. M .
AB Nitric oxide (NO) has long been recognized as a multifaceted participant in brain physiology. Despite the knowledge that was gathered over many years regarding the contribution of NO to neuronal plasticity, for example the ability of the brain to change in response to new stimuli, only in recent years have we begun to understand how NO acts on the molecular and cellular level to orchestrate such important phenomena as synaptic plasticity (modification of the strength of existing synapses) or the formation of new synapses (synaptogenesis) and new neurons (neurogenesis). Post-translational modification of proteins by NO derivatives or reactive nitrogen species is a non-classical mechanism for signalling by NO. S-nitrosation is a reversible post-translational modification of thiol groups (mainly on cysteines) that may result in a change of function of the modified protein. S-nitrosation of key target proteins has emerged as a main regulatory mechanism by which NO can influence several levels of brain plasticity, which are reviewed in this work. Understanding how S-nitrosation contributes to neural plasticity can help us to better understand the physiology of these processes, and to better address pathological changes in plasticity that are involved in the pathophysiology of several neurological diseases.
SN 0007-1188
SN 1476-5381
YR 2014
FD 2014-09-05
LK https://hdl.handle.net/20.500.14352/102882
UL https://hdl.handle.net/20.500.14352/102882
LA eng
NO FEDER funds via Programa Operacional Factores de Competitividade (COMPETE)
NO Foundation for Science and Technology (FCT, Portugal)
NO Spanish Government
DS Docta Complutense
RD 28 jul 2024