RT Journal Article
T1 Bacteria-Assisted Transport of Nanomaterials to Improve Drug Delivery in Cancer Therapy
A1 Jiménez Jiménez, Carla
A1 Moreno Zafra, Víctor Manuel
A1 Vallet Regí, María Dulce Nombre
AB Currently, the design of nanomaterials for the treatment of different pathologies is presenting a major impact on biomedical research. Thanks to this, nanoparticles represent a successful strat-egy for the delivery of high amounts of drugs for the treatment of cancer. Different nanosystems have been designed to combat this pathology. However, the poor penetration of these nano-materials into the tumor tissue prevents the drug from entering the inner regions of the tumor. Some bacterial strains have self-propulsion and guiding capacity thanks to their flagella. They also have a preference to accumulate in certain tumor regions due to the presence of different chemo-attractants factors. Bioconjugation reactions allow the binding of nanoparticles in living systems, such as cells or bacteria, in a simple way. Therefore, bacteria are being used as a transport vehicle for nanoparticles, facilitating their penetration and the subsequent release of the drug inside the tumor. This review would summarize the literature on the anchoring meth-ods of diverse nanosystems in bacteria and, interestingly, their advantages and possible applica-tions in cancer therapy.
PB MDPI
SN 2079-4991
YR 2022
FD 2022-01-17
LK https://hdl.handle.net/20.500.14352/71289
UL https://hdl.handle.net/20.500.14352/71289
LA eng
NO RESEARCHER ID M-3378-2014 (María Vallet Regí)ORCID 0000-0002-6104-4889 (María Vallet Regí)
NO Unión Europea. Horizonte 2020
DS Docta Complutense
RD 4 may 2024