RT Journal Article
T1 Osteogenic potential of a biomaterial enriched with osteostatin and mesenchymal stem cells in osteoporotic rabbits
A1 Luengo Alonso, Gonzalo
A1 Bravo Giménez, Beatriz
A1 Lozano Borregón, Daniel
A1 Heras, Clara
A1 Sánchez Salcedo, Sandra
A1 Benito Garzón, Lorena
A1 Abella García, Mónica
A1 Vallet Regí, María Dulce Nombre
A1 Cecilia López, David
A1 Salinas Sánchez, Antonio Jesús
AB Mesoporous bioactive glasses (MBGs) of the SiO2–CaO–P2O5 system are biocompatible materials with a quick and effective in vitro and in vivo bioactive response. MBGs can be enhanced by including therapeutically active ions in their composition, by hosting osteogenic molecules within their mesopores, or by decorating their surfaces with mesenchymal stem cells (MSCs). In previous studies, our group showed that MBGs, ZnO-enriched and loaded with the osteogenic peptide osteostatin (OST), and MSCs exhibited osteogenic features under in vitro conditions. The aim of the present study was to evaluate bone repair capability after large bone defect treatment in distal femur osteoporotic rabbits using MBGs (76%SiO2–15%CaO–5%P2O5–4%ZnO (mol-%)) before and after loading with OST and MSCs from a donor rabbit. MSCs presence and/or OST in scaffolds significantly improved bone repair capacity at 6 and 12 weeks, as confirmed by variations observed in trabecular and cortical bone parameters obtained by micro-CT as well as histological analysis results. A greater effect was observed when OST and MSCs were combined. These findings may indicate the great potential for treating critical bone defects by combining MBGs with MSCs and osteogenic peptides such as OST, with good prospects for translation to clinical practice.
PB MDPI
SN 2218-273X
YR 2024
FD 2024-01-23
LK https://hdl.handle.net/20.500.14352/104696
UL https://hdl.handle.net/20.500.14352/104696
LA eng
NO Luengo-Alonso G, Bravo-Gimenez B, Lozano D, Heras C, Sanchez-Salcedo S, Benito-Garzón L, Abella M, Vallet-Regi M, Cecilia-Lopez D, Salinas AJ. Osteogenic Potential of a Biomaterial Enriched with Osteostatin and Mesenchymal Stem Cells in Osteoporotic Rabbits. Biomolecules. 2024;14(2):143.
NO 2024 Descuento MDPI
NO Instituto de Salud Carlos III
NO Comisión Europea
NO Consejo Europeo de Investigación
NO Ministerio de Ciencia, Innovación y Universidades (España)
DS Docta Complutense
RD 26 abr 2025