RT Journal Article
T1 Phosphodiesterase-5 Expression in Buccal Mucosa of Patients with Erectile Dysfunction One Year after Radical Prostatectomy
A1 García-Cardoso, Juan
A1 Zamorano-León, José J.
A1 González-Enguita, Carmen
A1 Carbantes-Alarcon, David
A1 Zekri-Nechar, Khaoula
A1 Simón Adiego, Carlos María
A1 Jiménez García, Rodrigo
A1 López De Andrés, Ana Isabel
A1 Cuadrado Corrales, María Natividad
A1 Martínez Martínez, Carlos Hugo
AB (1) Background: Radical prostatectomy has a high incidence of erectile dysfunction (ED). The aim was to determine if the expression of the nitric oxide synthase-3/soluble guanylate cyclase/phosphodiesterase 5 axis could be detected in buccal mucosa and if it could be differently expressed in patients with and without ED; (2) Methods: Erectile function from 38 subjects subjected to prostatectomy was evaluated using the International Index of Erectile Function-Erectile Function Domain before and one year after surgery. Nitric oxide synthase (NOS3), beta 1-subunit of soluble guanylate cyclase (sGC), phosphodiesterase-5 (PDE-5) expressions, and interleukin-6 and interleukin-10 content were measured in the buccal mucosa. PDE5A rs3806808 gene polymorphism was genotyped; (3) Results: One year after prostatectomy, 15 patients had recovered functional erection, and 23 showed ED. NOS3, beta 1-sGC, interleukin-6, and interleukin-10 expressions were not different between patients with and without ED after radical prostatectomy. Buccal mucosa levels of PDE-5 were higher in patients with ED compared to those who recovered erectile functionality. There were no differences found in the genotype of PDE5A polymorphism; (4) Conclusions: One year after prostatectomy, patients with ED had higher PDE5 levels in their buccal mucosa than patients who had recovered erectile function. Rs3806808 PDE5A gene polymorphism was not associated with increased PDE5 expression in buccal mucosa.
PB MPDI
YR 2024
FD 2024-08-17
LK https://hdl.handle.net/20.500.14352/117922
UL https://hdl.handle.net/20.500.14352/117922
LA eng
NO García-Cardoso J, Zamorano-León JJ, González-Enguita C, Simón C, Jiménez-García R, López-de-Andrés A, Cuadrado-Corrales N, Carbantes-Alarcon D, Martínez-Martínez CH, Zekri-Nechar K. Phosphodiesterase-5 Expression in Buccal Mucosa of Patients with Erectile Dysfunction One Year after Radical Prostatectomy. J Pers Med. 2024 Aug 17;14(8):869
NO GenObIA Consortium of the Community of Madrid, Spain
NO Complutense University from Madrid, Spain
NO Fundación Jiménez Díaz
DS Docta Complutense
RD 11 abr 2025