RT Journal Article
T1 Pressurized Liquid (PLE) Truffle Extracts Have Inhibitory Activity on Key Enzymes Related to Type 2 Diabetes (α-Glucosidase and α-Amylase)
A1 Tejedor Calvo, Eva
A1 Morales Hernández, Diego
A1 Morillo, Laura
A1 Vega, Laura
A1 Caro, Mercedes
A1 Ribeiro Smiderle, Fhernanda
A1 Iacomini, Marcello
A1 Marco, Pedro
A1 Soler-Rivas, Cristina
AB An optimized PLE method was applied to several truffle species using three different solvent mixtures to obtain bioactive enriched fractions. The pressurized water extracts contained mainly (1 → 3),(1 → 6)-β-D-glucans, chitins, and heteropolymers with galactose and mannose in their structures. The ethanol extracts included fatty acids and fungal sterols and others such as brassicasterol and stigmasterol, depending on the species. They also showed a different fatty acid lipid profile depending on the solvent utilized and species considered. Ethanol:water extracts showed interesting lipids and many phenolic compounds; however, no synergic extraction of compounds was noticed. Some of the truffle extracts were able to inhibit enzymes related to type 2 diabetes; pressurized water extracts mainly inhibited the α-amylase enzyme, while ethanolic extracts were more able to inhibit α-glucosidase. Tuber brumale var. moschatum and T. aestivum var. uncinatum extracts showed an IC50 of 29.22 mg/mL towards α-amylase and 7.93 mg/mL towards α-glucosidase. Thus, use of the PLE method allows o bioactive enriched fractions to be obtained from truffles with antidiabetic properties.
PB MDPI
YR 2023
FD 2023-07-17
LK https://hdl.handle.net/20.500.14352/103970
UL https://hdl.handle.net/20.500.14352/103970
LA eng
NO Tejedor-Calvo, E., Morales, D., Morillo, L., Vega, L., Caro, M., Smiderle, F. R., Iacomini, M., Marco, P., & Soler-Rivas, C. (2023). Pressurized Liquid (PLE) Truffle Extracts Have Inhibitory Activity on Key Enzymes Related to Type 2 Diabetes (α-Glucosidase and α-Amylase). Foods (Basel, Switzerland), 12(14), 2724. https://doi.org/10.3390/foods12142724
NO 2022 Descuento MDPI
NO European Commission
DS Docta Complutense
RD 26 dic 2025