RT Journal Article
T1 Growth hormone replacement therapy prevents sarcopenia by a dual mechanism: improvement of protein balance and of antioxidant defenses
A1 Brioche, T.
A1 Kireev, Roman
A1 Cuesta Sancho, Sara
A1 Gratas Delamarche, A.
A1 Fernández-Tresguerres Hernández, Jesús Ángel
A1 Gómez Cabrera, M. C.
A1 Viña Ribes, Jose
AB The aim of our study was to elucidate the role of growth hormone (GH) replacement therapy in three of the main mechanisms involved in sarcopenia: alterations in mitochondrial biogenesis, increase in oxidative stress, and alterations in protein balance. We used young and old Wistar rats that received either placebo or low doses of GH to reach normal insulin-like growth factor-1 values observed in the young group. We found an increase in lean body mass and plasma and hepatic insulin-like growth factor-1 levels in the old animals treated with GH. We also found a lowering of age-associated oxidative damage and an induction of antioxidant enzymes in the skeletal muscle of the treated animals. GH replacement therapy resulted in an increase in the skeletal muscle protein synthesis and mitochondrial biogenesis pathways. This was paralleled by a lowering of inhibitory factors in skeletal muscle regeneration and in protein degradation. GH replacement therapy prevents sarcopenia by acting as a double-edged sword, antioxidant and hypertrophic
PB Oxford University Press
SN 1079-5006
YR 2013
FD 2013-12-03
LK https://hdl.handle.net/20.500.14352/99737
UL https://hdl.handle.net/20.500.14352/99737
LA eng
NO T. Brioche, R. A. Kireev, S. Cuesta, A. Gratas-Delamarche, J. A. Tresguerres, M. C. Gomez-Cabrera, J. Viña, Growth Hormone Replacement Therapy Prevents Sarcopenia by a Dual Mechanism: Improvement of Protein Balance and of Antioxidant Defenses, The Journals of Gerontology: Series A, Volume 69, Issue 10, October 2014, Pages 1186–1198, https://doi.org/10.1093/gerona/glt187
NO Ministerio de Educación y Ciencia
NO Instituto de Salud Carlos III
NO Generalitat Valenciana
NO Fundación  de  Investigación  del  Hospital  Clínico  Universitario  de  Valencia
NO Unión Europea
DS Docta Complutense
RD 10 abr 2025