RT Journal Article
T1 Overexpression of glycolysis markers in placental tissue of pregnant women with chronic venous disease: a histological study
A1 Ortega, Miguel Angel
A1 Sáez, Miguel A
A1 Fraile-Martínez, Oscar
A1 Álvarez-Mon, Miguel A
A1 García-Montero, Cielo
A1 Guijarro, Luis
A1 Asúnsolo, Ángel
A1 Álvarez-Mon, Melchor
A1 Bujan, Julia
A1 García-Honduvilla, Natalio
A1 León Luis, Juan Antonio
A1 Bravo Arribas, Coral
AB Chronic Venous Disease (CVD) refers to a wide variety of venous disorders being the varicose veins its most common manifestation. It is well-established the link between pregnancy and the risk of suffering CVD, due to hormonal or haematological factors, especially during the third trimester. In the same manner, previous studies have demonstrated the detrimental effect of this condition in the placental tissue of pregnant women, including in the normal physiology and the metabolomic profile of this organ. In this context, the aim of this study was to evaluate the glucose homeostasis in the placental tissue of women presenting CVD. Through immunohistochemistry, we studied the protein expression of the glucose transporter 1 (GLUT-1), Phosphoglycerate kinase 1 (PGK1), aldolase (ALD), Glyceraldehyde-3-phosphate dehydrogenase (GA3PDH) and lactate dehydrogenase (LDH). Our results have reported a significative increase in the expression of GLUT-1, PGK1, ALD, GA3PDH and the isoenzyme LDHA in placentas of women with CVD. This work has proven for the first-time an altered glucose metabolism in the placental tissue of women affected by CVD, what may aid to understand the pathophysiological mechanisms of this condition in more distant organs such as placenta. Furthermore, our research also supports the basis for further studies in the metabolic phenotyping of the human placenta due to CVD, which may be considered during the late pregnancy in these women.
PB Ivyspring International Publisher
SN 1449-1907
YR 2022
FD 2022-01-01
LK https://hdl.handle.net/20.500.14352/115185
UL https://hdl.handle.net/20.500.14352/115185
LA eng
NO Ortega MA, Sáez MA, Fraile-Martínez O, Álvarez-Mon MA, García-Montero C, Guijarro LG, Asúnsolo Á, Álvarez-Mon M, Bujan J, García-Honduvilla N, De León-Luis JA, Bravo C. Overexpression of glycolysis markers in placental tissue of pregnant women with chronic venous disease: a histological study. Int J Med Sci. 2022 Jan 1;19(1):186-194
NO Instituto de Salud Carlos III
NO European Development Regional Fund
NO Programas de Actividades de I+D de la Comunidad de Madrid B2017/BMD-3804 MITIC-CM
NO Halekulani S.L.
DS Docta Complutense
RD 25 abr 2025