RT Journal Article
T1 Safety assessment of chronic oral exposure to iron oxide nanoparticles
A1 Chamorro Francisco, Susana
A1 Gutiérrez, Lucía
A1 Vaquero, María Pilar
A1 Verdoy, Dolores
A1 Salas, Gorka
A1 Luengo, Yurena
A1 Brenes, Agustín
A1 Teran, Francisco José
AB Iron oxide nanoparticles with engineered physical and biochemical properties are finding a rapidly increasing number of biomedical applications. However, a wide variety of safety concerns, especially those related to oral exposure, still need to be addressed for iron oxide nanoparticles in order to reach clinical practice. Here, we report on the effects of chronic oral exposure to low doses of γ-Fe2O3 nanoparticles in growing chickens. Animal observation, weight, and diet intake reveal no adverse signs, symptoms, or mortality. No nanoparticle accumulation was observed in liver, spleen, and duodenum, with feces as the main excretion route. Liver iron level and duodenal villi morphology reflect the bioavailability of the iron released from the partial transformation of γ-Fe2O3 nanoparticles in the acid gastric environment. Duodenal gene expression studies related to the absorption of iron from γ-Fe2O3 nanoparticles indicate the enhancement of a ferric over ferrous pathway supporting the role of mucins. Our findings reveal that oral administration of iron oxide nanoparticles is a safe route for drug delivery at low nanoparticle doses.
SN 0957-4484
YR 2015
FD 2015
LK https://hdl.handle.net/20.500.14352/98088
UL https://hdl.handle.net/20.500.14352/98088
LA eng
NO Chamorro, Susana, et al. «Safety assessment of chronic oral exposure to iron oxide nanoparticles». Nanotechnology, vol. 26, n.o 20, mayo de 2015, p. 205101. https://doi.org/10.1088/0957-4484/26/20/205101.
NO Comunidad de Madrid
NO European Commission
NO Ministerio de Economía y Competitividad (España)
DS Docta Complutense
RD 31 dic 2025