%0 Journal Article
%A Luque, Jordi
%A Torres, María Isabel
%A Aumente, María Dolores
%A Marín, José
%A García-Jurado, Gema
%A González, Rafael
%A Pascual, Domingo
%A Guerra Pérez, Natalia
%A López-Rubio, Fernando
%A Alvarez-López, Rocío
%A Arizón, José
%A Peña, José
%T Soluble HLA-G in heart transplantation: their relationship to rejection episodes and immunosuppressive therapy
%D 2006
%@ 0198-8859
%U https://hdl.handle.net/20.500.14352/97737
%X The aims of this study were to quantify the level of soluble HLA-G in heart transplant patients, to determine the relationship between the sHLA-G levels and the appearance of acute rejection episodes, and to identify the influence of immunosuppressive therapy on sHLA-G levels. Analysis of sHLA-G, measured by enzyme-linked immunosorbent assay in the transplant patients, revealed the existence of two similarly sized groups of patients. One group displayed a significant increase (p < 0.001) in sHLA-G during the first month after transplantation while the other group maintained low levels of the molecule (0–30 ng/ml) throughout the study. The latter group displayed a high incidence of recurrent severe rejection. A significant increase (p < 0.01) in sHLA-G 2 hours after administration of immunosuppressive treatment (mycophenolate mofetil, cyclosporine A/FK506, corticoids) was found. These results suggest that sHLA-G participates in the induction of certain levels of immunological tolerance in these recipients.
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