RT Journal Article
T1 Twenty-four months of antipsychotic treatment in children and adolescents with first psychotic episode: discontinuation and tolerability
A1 Moreno Ruiz, María del Carmen
A1 Noguera A, 
A1 Ballesta P, 
A1 Baeza, I
A1 Arango López, Celso
A1 de la Serna E, 
A1 González-Pinto A, 
A1 Parellada Redondo, María José
A1 Graell M, 
A1 Otero S, 
A1 Castro-Fornieles J, 
AB Objective: The Child and Adolescent First-Episode Psychosis Study is a longitudinal study of early-onset first psychotic episodes. This report describes the naturalistic psychopharmacological treatment administered during a 24-month follow-up period, as well as discontinuation rates, reasons for discontinuation, and adverse effects.Methods: The sample comprised 110 patients, aged 9 to 17 years, with a first psychotic episode. Pharmacological treatment, changes, reasons for discontinuation, and the UKU (Udvalg for Kliniske Undersogelser) Side Effect Rating Scale were registered at 6, 12, and 24 months of follow-up.Results: Second-generation antipsychotics, especially risperidone, quetiapine, and olanzapine, were the most commonly used. The discontinuation rate was 44.5% at 6 months, 59.1% at 12 months, and 70.9% at 24 months. Discontinuation rates or reasons for discontinuation (adverse reaction, insufficient response, and other) did not differ significantly between antipsychotics. At 6 months, significant differences were found in body mass index increase and body mass index z score increase, which were higher with olanzapine, and in neurological effects, which were higher with risperidone; at 12 and 24 months, these differences were no longer significant. High maintenance rates were found in the clozapine group, although they had higher scores on the autonomic subscale of the UKU.Conclusions: A long follow-up period reveals high discontinuation rates similar to those observed in adults, particularly during the first year. No differences were found between antipsychotics. Differences in adverse effects were found at 6 months but not subsequently after changes in treatment. Clozapine had a high maintenance rate, and its tolerability was comparable to that of other antipsychotics.
PB Lippincott Williams & Wilkins
SN 0271-0749
YR 2013
FD 2013
LK https://hdl.handle.net/20.500.14352/115727
UL https://hdl.handle.net/20.500.14352/115727
LA eng
NO Noguera A, Ballesta P, Baeza I, Arango C, de la Serna E, González-Pinto A, Parellada M, Graell M, Moreno C, Otero S, Castro-Fornieles J. Twenty-four months of antipsychotic treatment in children and adolescents with first psychotic episode: discontinuation and tolerability. J Clin Psychopharmacol. 2013 Aug;33(4):463-71
NO Carlos III Institute of Health
NO Spanish Department of Health, Cooperative Research Thematic Network (RETICS)-G03/032
NO Spanish Ministry of Science and Innovation
NO CIBERSAM
NO Generalitat de Catalunya (to the Child Psychiatry and Psychology Group (2009 SGR1119))
DS Docta Complutense
RD 10 abr 2025