RT Journal Article
T1 Exploratory Longitudinal Study of Ocular Structural and Visual Functional Changes in Subjects at High Genetic Risk of Developing Alzheimer’s Disease
A1 López Cuenca, Inés
A1 García Martín, Elena Salobrar
A1 Barabash Bustelo, Ana
A1 Nebreda Pérez, Alberto
A1 Ramírez Toraño, Federico
A1 Sánchez Puebla, Lidia
A1 García Colomo, Alejandra
A1 Fernández Albarral, José
A1 Ramírez Sebastián, Ana Isabel
A1 Ramírez Sebastián, José Manuel
A1 Maestu Unturbe, Fernando
A1 Salazar Corral, Juan José
A1 Gil Gregorio, Pedro
A1 Álvarez Gutierrez, María
A1 Elvira Hurtado, Lorena
A1 Matamoros, José A.
A1 Hoz Montañana, María Rosa De
AB This study aimed to analyze the evolution of visual changes in cognitively healthy individuals at risk for Alzheimer’s disease (AD). Participants with a first-degree family history of AD (FH+) and carrying the Ε4+ allele for the ApoE gene (ApoE ε4+) underwent retinal thickness analysis using optical coherence tomography (OCT) and visual function assessments, including visual acuity (VA), contrast sensitivity (CS), color perception, perception digital tests, and visual field analysis. Structural analysis divided participants into FH+ ApoE ε4+ and FH− ApoE ε4− groups, while functional analysis further categorized them by age (40–60 years and over 60 years). Over the 27-month follow-up, the FH+ ApoE ε4+ group exhibited thickness changes in all inner retinal layers. Comparing this group to the FH− ApoE ε4− group at 27 months revealed progressing changes in the inner nuclear layer. In the FH+ ApoE ε4+ 40–60 years group, no progression of visual function changes was observed, but an increase in VA and CS was maintained at 3 and 12 cycles per degree, respectively, compared to the group without AD risk at 27 months. In conclusion, cognitively healthy individuals at risk for AD demonstrated progressive retinal structural changes over the 27-month follow-up, while functional changes remained stable.
PB MDPI
SN 2227-9059
YR 2023
FD 2023-07-18
LK https://hdl.handle.net/20.500.14352/87403
UL https://hdl.handle.net/20.500.14352/87403
LA eng
NO This article belongs to the Special Issue Neurodegenerative Diseases: Recent Advances and Future Perspectives.Received: 19 June 2023 ; Revised: 6 July 2023 ; Accepted: 12 July 2023 ; Published: 18 July 2023
NO Ministerio de Economía y Competitividad (España)
NO Instituto de Salud Carlos III (España)
NO Ministerio de Ciencia e Innovación (España)
NO Ministerio de Economía (España)
NO Universidad Complutense de Madrid
DS Docta Complutense
RD 10 may 2025