RT Journal Article
T1 An Odorant-Binding Protein as a New Allergen from Siberian Hamster (Phodopus sungorus)
A1 Torres, J.A.
A1 Pastor Vargas, Carlos
A1 de las Heras, M.
A1 Vivanco Martínez, Fernando
A1 Cuesta, Javier
A1 Sastre, J.
AB A case of anaphylaxis following a bite from a Siberian hamster (SH; Phodopus sungorus) is described. Skin prick tests with hair, urine and salivary gland extracts from SH were positive, while the tests were negative for hair extracts from other rodents. IgE immunoblotting with the patient serum revealed 3 IgE-binding bands of about 18, 21 and 23 kDa. When the patient's serum was preincubated with rabbit, mouse and gerbil hair extracts, no inhibition of the 3 SH IgE-binding bands was demonstrated. Proteins extracted from the 3 bands were analyzed by N-terminal sequencing and matrix-assisted laser desorption/ionization time-of-flight tandem mass spectrometry, and peptides were sequenced. IgE-binding bands were identified as being an odorant-binding protein belonging to the lipocalin family. Analysis of the 3 IgE-binding bands found in the hair, urine and salivary glands of SH showed a new allergenic protein lacking cross-reactivity with allergens from other rodents. The 3 bands likely correspond to isoforms of a single allergen.
PB Karger
SN 1018-2438
SN 1423-0097
YR 2011
FD 2011-09-07
LK https://hdl.handle.net/20.500.14352/107042
UL https://hdl.handle.net/20.500.14352/107042
LA eng
NO Torres JA, Pastor-Vargas C, de las Heras M, Vivanco F, Cuesta J, Sastre J. An odorant-binding protein as a new allergen from Siberian hamster (Phodopus sungorus). Int Arch Allergy Immunol. 2012;157(1):109-12. doi: 10.1159/000324956. Epub 2011 Sep 7. PMID: 21912180.
DS Docta Complutense
RD 31 ago 2024