RT Journal Article
T1 Apoptosis, Toll-like, RIG-I-like and NOD-like Receptors Are Pathways Jointly Induced by Diverse Respiratory Bacterial and Viral Pathogens
A1 Martínez, Isidoro
A1 Oliveros, Juan
A1 Cuesta, Isabel
A1 Barrera, Jorge
A1 Ausina, Vicente
A1 Casals Carro, María Cristina
A1 Lorenzo, Alba de
A1 García, Ernesto
A1 García-Fojeda García-Valdecasas, María Belén
A1 Garmendia, Junkal
A1 González-Nicolau, Mar
A1 Lacoma, Alicia
A1 Menéndez, Margarita
A1 Moranta, David
A1 Nieto, Amelia
A1 Ortín, Juan
A1 Pérez-González, Alicia
A1 Prat, Cristina
A1 Ramos-Sevillano, Elisa
A1 Regueiro, Verónica
A1 Rodriguez-Frandsen, Ariel
A1 Solís, Dolores
A1 Yuste, José
A1 Bengoechea, José
A1 Melero, José
AB Lower respiratory tract infections are among the top five leading causes of human death. Fighting these infections is therefore a world health priority. Searching for induced alterations in host gene expression shared by several relevant respiratory pathogens represents an alternative to identify new targets for wide-range host-oriented therapeutics. With this aim, alveolar macrophages were independently infected with three unrelated bacterial (Streptococcus pneumoniae, Klebsiella pneumoniae, and Staphylococcus aureus) and two dissimilar viral (respiratory syncytial virus and influenza A virus) respiratory pathogens, all of them highly relevant for human health. Cells were also activated with bacterial lipopolysaccharide (LPS) as a prototypical pathogen-associated molecular pattern. Patterns of differentially expressed cellular genes shared by the indicated pathogens were searched by microarray analysis. Most of the commonly up-regulated host genes were related to the innate immune response and/or apoptosis, with Toll-like, RIG-I-like and NOD-like receptors among the top 10 signaling pathways with over-expressed genes. These results identify new potential broad-spectrum targets to fight the important human infections caused by the bacteria and viruses studied here.
PB Frontiers
SN 1664-302X
YR 2017
FD 2017
LK https://hdl.handle.net/20.500.14352/94519
UL https://hdl.handle.net/20.500.14352/94519
LA eng
NO Martínez I, Oliveros JC, Cuesta I, de la Barrera J, Ausina V, Casals C, de Lorenzo A, García E, García-Fojeda B, Garmendia J, González-Nicolau M, Lacoma A, Menéndez M, Moranta D, Nieto A, Ortín J, Pérez-González A, Prat C, Ramos-Sevillano E, Regueiro V, Rodriguez-Frandsen A, Solís D, Yuste J, Bengoechea JA and Melero JA (2017) Apoptosis, Toll-like, RIG-I-like and NOD-like Receptors Are Pathways Jointly Induced by Diverse Respiratory Bacterial and Viral Pathogens. Front. Microbiol. 8:276. doi: 10.3389/fmicb.2017.00276
NO Instituto de Salud Carlos III
NO Ministerio de Economía y Competitividad (España)
NO Sociedad Española de Neumología y Cirugía Torácica
NO European Commission
DS Docta Complutense
RD 11 ago 2024