RT Journal Article
T1 The impact of nanomaterials on autophagy across health and disease conditions
A1 Florance, Ida
A1 Cordani, Marco
A1 Pashootan, Parya
A1 Moosavi, Mohammad Amin
A1 Zarrabi, Ali
A1 Chandrasekaran, Natarajan
A2 Springer, 
AB Autophagy, a catabolic process integral to cellular homeostasis, is constitutively active under physiological and stress conditions. The role of autophagy as a cellular defense response becomes particularly evident upon exposure to nanomaterials (NMs), especially environmental nanoparticles (NPs) and nanoplastics (nPs). This has positioned autophagy modulation at the forefront of nanotechnology-based therapeutic interventions. While NMs can exploit autophagy to enhance therapeutic outcomes, they can also trigger it as a pro-survival response against NP-induced toxicity. Conversely, a heightened autophagy response may also lead to regulated cell death (RCD), in particular autophagic cell death, upon NP exposure. Thus, the relationship between NMs and autophagy exhibits a dual nature with therapeutic and environmental interventions. Recognizing and decoding these intricate patterns are essential for pioneering next-generation autophagy-regulating NMs. This review delves into the present-day therapeutic potential of autophagy-modulating NMs, shedding light on their status in clinical trials, intervention of autophagy in the therapeutic applications of NMs, discusses the potency of autophagy for application as early indicator of NM toxicity.
PB Springer
SN 1420-682X
YR 2024
FD 2024-04-17
LK https://hdl.handle.net/20.500.14352/104033
UL https://hdl.handle.net/20.500.14352/104033
LA eng
NO 2024 Acuerdos transformativos CRUE
NO European Union
NO Ministerio de Ciencia, Innovación y Universidades (España)
NO Indian Council of Medical Research
NO National Institute of Genetic Engineering and Biotechnology (Iran)
DS Docta Complutense
RD 17 abr 2025