RT Journal Article
T1 New perspectives in hydrogenase direct electrochemistry
A1 Sensi, Matteo
A1 Del Barrio Redondo, Melisa
A1 Baffert, Carole
A1 Fourmond, Vincent
A1 Léger, Christophe
AB Electrochemical studies of hydrogenases, the biological catalysts of H2 oxidation and production, have proven wrong the old saying that enzymes do not easily transfer electrons to electrodes in the absence of mediators. Many distinct hydrogenases have actually been directly connected to electrodes or particles, for studying their catalytic mechanism or for designing solar-fuels catalysts. In this review, we list the electrodes that have proved successful for direct electron transfer to hydrogenases, and we discuss recent results which illustrate new directions in this research field: the study of the biosynthesis of FeFe hydrogenase, the electrochemical characterization of non-standard NiFe or FeFe hydrogenases, the general discussion of what makes a catalyst better in one particular direction of the reaction, and the elucidation of the molecular mechanisms of hydrogenase catalysis by combining electrochemistry and theoretical chemistry, spectroscopy or photochemistry. The electrochemical methods described herein will probably prove useful for studying or using other redox enzymes.
PB Elsevier
SN 2451-9103
YR 2017
FD 2017
LK https://hdl.handle.net/20.500.14352/92997
UL https://hdl.handle.net/20.500.14352/92997
LA eng
NO Sensi, M., del Barrio, M., Baffert, C., Fourmond, V., & Léger, C. (2017). New perspectives in hydrogenase direct electrochemistry. Current Opinion in Electrochemistry, 5(1), 135-145.
NO Centre national de la recherche scientifique (Francia)
NO Université Aix Marseille 
NO Agence Nationale de la Recherche (Francia)
DS Docta Complutense
RD 18 abr 2025