RT Journal Article
T1 Biotin-functionalized nanoparticles: an overview of recent trends in cancer detection
A1 Fathi-karkan, Sonia
A1 Sargazi, Saman
A1 Shojaei, Shirin
A1 Farasati Far, Bahareh
A1 Mirinejad, Shekoufeh
A1 Cordani, Marco
A1 Khosravi, Arezoo
A1 Zarrabi, Ali
A1 Ghavami, Saeid
AB Electrochemical bio-sensing is a potent and efficient method for converting various biological recognition events into voltage, current, and impedance electrical signals. Biochemical sensors are now a common part of medical applications, such as detecting blood glucose levels, detecting food pathogens, and detecting specific cancers. As an exciting feature, bio-affinity couples, such as proteins with aptamers, ligands, paired nucleotides, and antibodies with antigens, are commonly used as bio-sensitive elements in electrochemical biosensors. Biotin–avidin interactions have been utilized for various purposes in recent years, such as targeting drugs, diagnosing clinically, labeling immunologically, biotechnology, biomedical engineering, and separating or purifying biomolecular compounds. The interaction between biotin and avidin is widely regarded as one of the most robust and reliable noncovalent interactions due to its high bi-affinity and ability to remain selective and accurate under various reaction conditions and bio-molecular attachments. More recently, there have been numerous attempts to develop electrochemical sensors to sense circulating cancer cells and the measurement of intracellular levels of protein thiols, formaldehyde, vitamin-targeted polymers, huwentoxin-I, anti-human antibodies, and a variety of tumor markers (including alpha-fetoprotein, epidermal growth factor receptor, prostate-specific Ag, carcinoembryonic Ag, cancer antigen 125, cancer antigen 15-3, etc.). Still, the non-specific binding of biotin to endogenous biotin-binding proteins present in biological samples can result in false-positive signals and hinder the accurate detection of cancer biomarkers. This review summarizes various categories of biotin-functional nanoparticles designed to detect such biomarkers and highlights some challenges in using them as diagnostic tools.
PB The Royal Society of Chemistry
SN 2040-3364
YR 2024
FD 2024-06-10
LK https://hdl.handle.net/20.500.14352/118688
UL https://hdl.handle.net/20.500.14352/118688
LA eng
NO Fathi-Karkan, S., Sargazi, S., Shojaei, S., Farasati Far, B., Mirinejad, S., Cordani, M., Khosravi, A., Zarrabi, A., & Ghavami, S. (2024). Biotin-functionalized nanoparticles: an overview of recent trends in cancer detection [Review of Biotin-functionalized nanoparticles: an overview of recent trends in cancer detection]. Nanoscale, 16(27), 12750-12792. Royal Society of Chemistry. https://doi.org/10.1039/D4NR00634H
NO Marco Cordani was supported by grant RYC2021-031003I funded by MICIU/AEI/10.13039/501100011033 and by European Union NextGenerationEU/PRTR.
NO Ministerio de Ciencia, Innovación y Universidades (España)
NO European Commission
NO Universidad Complutense de Madrid
DS Docta Complutense
RD 16 abr 2025