RT Journal Article
T1 The orphan G protein-coupled receptor GPR55 promotes cancer cell proliferation via ERK
A1 Andradas Heranz, Carlos
A1 Caffarel Serra, Carmen
A1 Pérez Gómez, Eduardo
A1 Salazar Roa, María
A1 Lorente Pérez, María Del Mar
A1 Velasco Díez, Guillermo
A1 Guzmán Pastor, Manuel
A1 Sánchez García, María Cristina
AB GPR55 is an orphan G protein-coupled receptor that may be engaged by some lipid ligands such as lysophosphatidylinositol and cannabinoid-type compounds. Very little is known about its expression pattern and physio-pathological relevance, and its pharmacology and signaling are still rather controversial. Here we analyzed the expression and function of GPR55 in cancer cells. Our data show that GPR55 expression in human tumors from different origins correlates with their aggressiveness. Moreover, GPR55 promotes cancer cell proliferation, both in cell cultures and in xenografted mice, through the overactivation of the extracellular signal-regulated kinase cascade. These findings reveal the importance of GPR55 in human cancer, and suggest that it could constitute a new biomarker and therapeutic target in oncology.
PB Springernature
SN 0950-9232
YR 2010
FD 2010
LK https://hdl.handle.net/20.500.14352/97949
UL https://hdl.handle.net/20.500.14352/97949
LA eng
NO Andradas, C., Caffarel, M., Pérez-Gómez, E. et al. The orphan G protein-coupled receptor GPR55 promotes cancer cell proliferation via ERK. Oncogene 30, 245–252 (2011). https://doi.org/10.1038/onc.2010.402
NO Ministerio de Ciencia e Innovación (España)
NO Fundación Ferrer para la Investigación
NO Comunidad de Madrid
NO Fundación Mutua Madrileña
NO Otsuka Pharmaceuticals
DS Docta Complutense
RD 4 abr 2025