RT Journal Article
T1 Segmentally homologous neurons acquire two different terminal neuropeptidergic fates in the Drosophila nervous system
A1 Gabilondo, Hugo
A1 Rubio-Ferrera, Irene
A1 Losada Pérez, María De La Paloma
A1 Saz, Delia del
A1 Leon, Yolanda
A1 Molina, Isabel
A1 Allan, Douglas
A1 Benito-Sipos, Jonathan
AB In this study, we identify the means by which segmentally homologous neurons acquire different neuropeptide fates in Drosophila. Ventral abdominal (Va)-neurons in the A1 segment of the ventral nerve cord express DH31 and AstA neuropeptides (neuropeptidergic fate I) by virtue of Ubx activity, whereas the A2-A4 Va-neurons express the Capa neuropeptide (neuropeptidergic fate II) under the influence of abdA. These different fates are attained through segment-specific programs of neural subtype specification undergone by segmentally homologous neurons. This is an attractive alternative by which Hox genes can shape Drosophila segmental neural architecture (more sophisticated than the previously identified binary "to live" or "not to live" mechanism). These data refine our knowledge of the mechanisms involved in diversifying neuronal identity within the central nervous system.
PB Public Library of Science
YR 2018
FD 2018-04-10
LK https://hdl.handle.net/20.500.14352/107551
UL https://hdl.handle.net/20.500.14352/107551
LA eng
NO Gabilondo, H., Rubio-Ferrera, I., Losada-Pérez, M., Del Saz, D., León, Y., Molina, I., Torroja, L., W Allan, D., & Benito-Sipos, J. (2018). Segmentally homologous neurons acquire two different terminal neuropeptidergic fates in the Drosophila nervous system. PloS One, 13(4), e0194281. https://doi.org/10.1371/journal.pone.0194281
NO Ministerio de Economía y Competitividad (España)
DS Docta Complutense
RD 22 abr 2025