RT Journal Article
T1 Proteolytic Enzymes and Cavitation as Strategies to Enhanced Penetration of Drug Nanocarriers
A1 Villegas, Maria Rocio
A1 Baeza, Alejandro
A1 Vallet Regí, María Dulce Nombre
AB The poor penetration of drug nanocarriers within tumor tissues is one of the most critical factors which limit their effectiveness. Nanomedicine has developed different strategies in order to overcome this important hurdle. Some of these strategies are based on the degradation of the highly dense extracellular matrix (ECM) which is usually present in many solid tumors. In this sense, one of the most promising approaches consists in the nanoparticle decoration with proteolytic enzymes able to digest the ECM favoring its penetration. Other strategy is based on the capacity of ultrasounds to induce cavitation which propels the nanocarriers to deep areas into the tumor. Both strategies have demonstrated significant improvement in the penetration of nanocarriers in malignant tissues, enhancing their effectivity.
PB MedCrave
SN 2574-9927
YR 2018
FD 2018-02-09
LK https://hdl.handle.net/20.500.14352/11967
UL https://hdl.handle.net/20.500.14352/11967
LA eng
NO RESEARCHER ID V-7077-2017 (María Rocío Villegas Díaz)ORCID 0000-0002-1297-2355 (María Rocío Villegas Díaz)RESEARCHER ID K-8193-2014 (Alejandro Baeza)ORCID 0000-0002-2026-6266 (Alejandro Baeza)RESEARCHER ID M-3378-2014 (María Vallet Regí)ORCID 0000-0002-6104-4889 (María Vallet Regí)
NO Unión Europea. H2020
NO Ministerio de Economía y Competitividad (MINECO)
DS Docta Complutense
RD 6 may 2024