RT Journal Article
T1 BMP8 and activated brown adipose tissue in human newborns
A1 Urisarri, Adela
A1 González García, Ismael
A1 Estévez Salguero, Ánxela
A1 Pata, María P.
A1 Milbank, Edward
A1 López Ejeda, Noemí
A1 Mandiá, Natalia
A1 Grijota Martínez, María Carmen
A1 Salgado, Carlos A.
A1 Nogueiras, Rubén
A1 Diéguez, Carlos
A1 Villarroya, Francesc
A1 Fernández Real, José-Manuel
A1 Couce, María L.
A1 López, Miguel
AB The classical dogma states that brown adipose tissue (BAT) plays a major role in the regulation of temperature in neonates. However, although BAT has been studied in infants for more than a century, the knowledge about its physiological features at this stage of life is rather limited. This has been mainly due to the lack of appropriate investigation methods, ethically suitable for neonates. Here, we have applied non-invasive infrared thermography (IRT) to investigate neonatal BAT activity. Our data show that BAT temperature correlates with body temperature and that mild cold stimulus promotes BAT activation in newborns. Notably, a single short-term cold stimulus during the first day of life improves the body temperature adaption to a subsequent cold event. Finally, we identify that bone morphogenic protein 8B (BMP8B) is associated with the BAT thermogenic response in neonates. Overall, our data uncover key features of the setup of BAT thermogenesis in newborns.
PB Nature Publishing Group
SN 2041-1723
YR 2021
FD 2021
LK https://hdl.handle.net/20.500.14352/7210
UL https://hdl.handle.net/20.500.14352/7210
LA eng
NO Acknoledgements: Miguel López thanks María López-Piñeiro, Sara López-Piñeiro, Marta López-Piñeiro, and Irene Piñeiro for the opportunity to do this work and because he would never have done this study without them. He also thanks all the clinical staff of Neonatology Service, of University Clinical Hospital of Santiago de Compostela for their outstanding support, help, and assistance during November 2014. The research leading to these results has received funding from the Xunta de Galicia (R.N.: 2016-PG057; M.L.: 2016-PG068); Ministerio de Economía y Competitividad (MINECO) co-funded by the FEDER Program of EU (R.N.: RTI2018-099413-B-I00; C.D.: BFU2017-87721-P; F.V.: SAF2017-85722-R; M.L.: RTI2018-101840-B-I00: F.V., J.M.F.-R., and M.L.: BFU2017-90578-REDT/Adipoplast); Instituto de Salud Carlos III (J.M.F.-R.: PI15-01934); Atresmedia Corporación (R.N. and M.L.); Fundación BBVA (R.N.); la Caixa Foundation (ID 100010434), under the agreement LCF/PR/HR19/52160022 (M.L.); European Foundation for the Study of Diabetes (R.N.) and ERC Synergy Grant-2019-WATCH- 810331 (R.N.) and Research Grant SOPEGA 2016 (A.U. and M.L.C.). F.V. is an ICREA Academia researcher (Generalitat de Catalunya). I.G.-G. is the recipient of a fellowship from the European Union’s Horizon 2020 research and innovation program under the Marie Sklodowska-Curie actions. The CiMUS is supported by the Xunta de Galicia (2016-2019, ED431G/05). CIBER de Fisiopatología de la Obesidad y Nutrición is an initiative of ISCIII. The funders had no role in study design, data collection, and analysis, decision to publish, or preparation of the paper.
NO Unión Europea
NO Ministerio de Economía, Comercio y Empresa (España)/Fondo Europeo de Desarrollo Regional
NO Instituto de Salud Carlos III
NO European Foundation for the Study of Diabetes and ERC
NO Xunta de Galicia
NO Generalitat de Catalunya
NO Fundación Caixaforum
NO Fundación BBVA
NO European Foundation for the Study of Diabetes
NO Atresmedia Corporación
DS Docta Complutense
RD 24 abr 2025