RT Journal Article
T1 Effects of Substituents on Photophysical and CO-Photoreleasing Properties of 2,6-Substituted meso-Carboxy BODIPY Derivatives †
A1 Sánchez-Carnerero, Esther M.
A1 Russo, Marina
A1 Jakob, Andreas
A1 Muchová, Lucie
A1 Vítek, Libor
A1 Klán, Petr
AB Carbon monoxide (CO) is an endogenously produced signaling molecule involved in the control of a vast array of physiological processes. One of the strategies to administer therapeutic amounts of CO is the precise spatial and temporal control over its release from photoactivatable CO-releasing molecules (photoCORMs). Here we present the synthesis and photophysical and photochemical properties of a small library of meso-carboxy BODIPY derivatives bearing different substituents at positions 2 and 6. We show that the nature of substituents has a major impact on both their photophysics and the efficiency of CO photorelease. CO was found to be efficiently released from π-extended 2,6-arylethynyl BODIPY derivatives possessing absorption spectra shifted to a more biologically desirable wavelength range. Selected photoCORMs were subjected to in vitro experiments that did not reveal any serious toxic effects, suggesting their potential for further biological research.
PB MDPI
SN 2624-8549
YR 2021
FD 2021
LK https://hdl.handle.net/20.500.14352/7487
UL https://hdl.handle.net/20.500.14352/7487
LA eng
NO Czech Science Foundation
NO Czech Ministry of Health
NO Czech Ministry of Education, Youth, and Sports
NO RECETOX research infrastructure
DS Docta Complutense
RD 10 abr 2025