RT Journal Article T1 Changes in retinal nerve fiber layer thickness measurements in response to a trifocal intraocular lens implantation A1 García-Bella, Javier A1 Talavero-González, Paula A1 Carballo Álvarez, Jesús A1 Sanz Fernández, Jesús A1 Vázquez-Moliní, Jesús A1 García Feijoo, Julián A1 Martínez De La Casa Fernández-Borrella, José María AB Aims: To determine the changes produced on the peripapillary retinal nerve fiber layer (RNFL) thickness, measured by an spectral-domain optical coherence tomography (OCT), after the implantation of a trifocal diffractive intraocular lens (IOL) and compare them with the variations produced by a monofocal IOL implantation.Methods: A prospective, double masked study in which 50 eyes belonging to 50 patients with bilateral cataract were enrolled. Sequentially, the first 25 patients were bilaterally implanted with the trifocal diffractive IOL AT LISA® Tri 839 MP and the following 25 patients with the monofocal IOL CT ASPHINA® 409 M/MP. RNFL thickness measurements were performed by Cirrus HD®-OCT before and six months after the second eye surgery.Results: Mean patient age was 69.5 ± 6.1 years. In response to surgery, the average RNFL thickness increased 7.29 ± 10.51 µm at the AT LISA® Tri group and 1.96 ± 2.90 µm at the monofocal IOL group from the baseline (p = 0.017). Statistically significant differences in thickness variations were also detected in the superior sector (7.86 ± 7.70 µm at the AT LISA® Tri group vs 1.73 ± 5.74 µm at the monofocal group). Statistically significant differences between the pre and the postsurgery measurements were found in all sectors except the inferior one with the trifocal IOL and in two of the studied sectors (average and temporal) with the monofocal IOL.Conclusions: The IOL implantation produce changes in the RNFL thickness, which are larger in case of a trifocal diffractive IOL. PB Springer YR 2018 FD 2018-06-11 LK https://hdl.handle.net/20.500.14352/113567 UL https://hdl.handle.net/20.500.14352/113567 LA eng NO García-Bella J, Talavero-González P, Carballo-Álvarez J, Sanz-Fernández JC, Vázquez-Moliní JM, García-Feijóo J, Martínez-de-la-Casa JM. Changes in retinal nerve fiber layer thickness measurements in response to a trifocal intraocular lens implantation. Eye (Lond). 2018 Oct;32(10):1574-1578. doi: 10.1038/s41433-018-0141-0. Epub 2018 Jun 11. PMID: 29891898; PMCID: PMC6189210. DS Docta Complutense RD 8 abr 2025