RT Journal Article
T1 Blood Neutrophil Counts Define Specific Clusters of Bronchiectasis Patients: A Hint to Differential Clinical Phenotypes
A1 Wang, Xuejie
A1 Olveira, Casilda
A1 Girón, Rosa
A1 García Clemente, Marta
A1 Máiz, Luis
A1 Sibila, Oriol
A1 Golpe, Rafael
A1 Menéndez, Rosario
A1 Rodríguez López, Juan Pedro
A1 Prados, Concepción
A1 Martinez García, Miguel Angel
A1 Rodriguez Hermosa, Juan Luis
A1 Rosa, David de la
A1 Qin, Liyun
A1 Duran, Xavier
A1 Garcia Ojalvo, Jordi
A1 Barreiro, Esther
AB We sought to investigate differential phenotypic characteristics according to neutrophil counts, using a biostatistics approach in a large-cohort study from the Spanish Online Bronchiectasis Registry (RIBRON). The 1034 patients who met the inclusion criteria were clustered into two groups on the basis of their blood neutrophil levels. Using the Mann–Whitney U test to explore potential differences according to FACED and EFACED scores between the two groups, a neutrophil count of 4990 cells/µL yielded the most balanced cluster sizes: (1) above-threshold (n = 337) and (2) below-threshold (n = 697) groups. Patients above the threshold showed significantly worse lung function parameters and nutritional status, while systemic inflammation levels were higher than in the below-threshold patients. In the latter group, the proportions of patients with mild disease were greater, while a more severe disease was present in the above-threshold patients. According to the blood neutrophil counts using biostatistics analyses, two distinct clinical phenotypes of stable patients with non-CF bronchiectasis were defined. Patients falling into the above-threshold cluster were more severe. Severity was characterized by a significantly impaired lung function parameters and nutritional status, and greater systemic inflammation. Phenotypic profiles of bronchiectasis patients are well defined as a result of the cluster analysis of combined systemic and respiratory variables.
PB MPDI
SN 2227-9059
YR 2022
FD 2022-04-30
LK https://hdl.handle.net/20.500.14352/71613
UL https://hdl.handle.net/20.500.14352/71613
LA eng
NO Ministerio de Ciencia e Innovación (MICINN)
NO Instituto de Salud Carlos III (ISCIII)/ FEDER
DS Docta Complutense
RD 31 jul 2024