TY  - JOUR
AU  - Martínez Cisuelo, V.
AU  - Gómez, J.
AU  - García Junceda, I.
AU  - Naudí, Alba
AU  - Cabré, R.
AU  - Mota Martorell, N.
AU  - López Torres, Mónica
AU  - González Sánchez, Mónica
AU  - Pamplona, R.
AU  - Barja de Quiroga, Gustavo
PY  - 2016
DO  - 10.1016/j.exger.2016.08.002
SN  - 0531-5565
UR  - https://hdl.handle.net/20.500.14352/17774
T2  - Experimental Gerontology
AB  - Rapamycin consistently increases longevity in mice although the mechanism of action of this drug is unknown. In the present investigation we studied the effect of rapamycin on mitochondrial oxidative stress at the same dose that is known to increase...
LA  - eng
M2  - 130
PB  - Elsevier
KW  - Rapamycin
KW  - Lipofuscin
KW  - Mitochondria
KW  - Free radicals
KW  - Tor
KW  - Aging
TI  - Rapamycin reverses age-related increases in mitochondrial ROS production at complex I, oxidative stress, accumulation of mtDNA fragments inside nuclear DNA, and lipofuscin level, and increases autophagy, in the liver of middle-aged mice
TY  - journal article
VL  - 83
ER  -