RT Journal Article
T1 Relationship between CDC cross-match in liver recipients and antibody screening by flow cytometry
A1 Muro, Manuel
A1 Sánchez-Bueno, Francisco
A1 Marín, Luis Alberto
A1 Torío, Alberto
A1 Moya-Quiles, María Rosa
A1 Minguela, Alfredo
A1 Montes, Olga
A1 Guerra Pérez, Natalia
A1 Arana Montes, María Del Pilar De
A1 Pérez-López, Maria José
A1 Robles, Ricardo
A1 Ramirez, Pablo
A1 García-Alonso, Ana María
A1 Parrilla, Pacual
A1 Álvarez-López, María Rocio
AB Several authors have shown that anti-donor antibodies before liver transplantation are associated with decreased graft survival. The aim of this study was to investigate the relationship between anti-donor antibodies detected by the CDC technique or by FlowPRA, and acute or chronic rejection as well as graft survival. Furthermore, we sought to determine whether anti-donor antibodies, detected by the CDC technique, correlated with those discovered by cytometric screening. The acute rejection incidence among patients with complement-dependent cytotoxicity positive CDC cross-match was similar to that for patients with a negative cross-match. None of the patients with a positive cross-match developed chronic rejection. Allograft survival was significantly lower among recipients with a positive T-lymphocyte cross-match. Indeed, the majority of recipients with positive CDC cross-matches displayed graft failures before first postransplant year. The results of a positive FlowPRA determination were concordant with a positive CDC cross-match in 85.71% of cases. Our data demonstrate that pretransplant FlowPRA correlates with the final CDC cross-match results. This finding suggests that in the future prospective pretransplant antibody screening with FlowPRA or CDC techniques may be useful to identify high-risk recipients.
PB Elsevier
SN 0041-1345
YR 2003
FD 2003
LK https://hdl.handle.net/20.500.14352/97963
UL https://hdl.handle.net/20.500.14352/97963
LA eng
NO Muro, M., et al. «Relationship between CDC Cross-Match in Liver Recipients and Antibody Screening by Flow Cytometry». Transplantation Proceedings, vol. 35, n.o 5, agosto de 2003, pp. 1894-95. https://doi.org/10.1016/S0041-1345(03)00639-0.
DS Docta Complutense
RD 6 abr 2025