%0 Journal Article
%A Blizinsky, Katherine D.
%A Diaz-Castro, Blanca
%A Forrest, Marc P.
%A Schürmann,, Britta
%A Bach, Anthony P.
%A Martín De Saavedra Álvarez De Uribarri, María Dolores
%A Wang, Lei
%A Csernansky, John G.
%A Duan, Jubao
%A Penzes, Peter
%T Reversal of dendritic phenotypes in 16p11.2 microduplication mouse model neurons by pharmacological targeting of a network hub
%D 2016
%@ 0027-8424
%U https://hdl.handle.net/20.500.14352/93463
%X The architecture of neuronal dendritic trees is crucial for brain connectivity, whereas dendritic abnormalities are associated with psychiatric disorders. Rare copy number variations (CNVs) are a category of mutations often associated with schizophrenia, autism, and other mental disorders. However, the genetic complexity of CNV disorders poses a serious challenge for the identification of experimentally approachable mechanisms. Here we used network analysis to identify the most topologically important hub in protein–protein interaction networks within such a CNV, and in broader gene networks of psychiatric CNVs. We then show that pharmacological targeting of this node reverses dendritic alterations in a neuronal model of this CNV, outlining a strategy for the analysis and reversal of cellular phenotypes in CNV-related psychiatric disorders.
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