RT Journal Article
T1 Reversal of dendritic phenotypes in 16p11.2 microduplication mouse model neurons by pharmacological targeting of a network hub
A1 Blizinsky, Katherine D.
A1 Diaz-Castro, Blanca
A1 Forrest, Marc P.
A1 Schürmann, , Britta
A1 Bach, Anthony P.
A1 Martín De Saavedra Álvarez De Uribarri, María Dolores
A1 Wang, Lei
A1 Csernansky, John G.
A1 Duan, Jubao
A1 Penzes, Peter
AB The architecture of neuronal dendritic trees is crucial for brain connectivity, whereas dendritic abnormalities are associated with psychiatric disorders. Rare copy number variations (CNVs) are a category of mutations often associated with schizophrenia, autism, and other mental disorders. However, the genetic complexity of CNV disorders poses a serious challenge for the identification of experimentally approachable mechanisms. Here we used network analysis to identify the most topologically important hub in protein–protein interaction networks within such a CNV, and in broader gene networks of psychiatric CNVs. We then show that pharmacological targeting of this node reverses dendritic alterations in a neuronal model of this CNV, outlining a strategy for the analysis and reversal of cellular phenotypes in CNV-related psychiatric disorders.
PB National Academy of Sciences
SN 0027-8424
YR 2016
FD 2016
LK https://hdl.handle.net/20.500.14352/93463
UL https://hdl.handle.net/20.500.14352/93463
LA eng
NO Blizinsky KD, Diaz-Castro B, Forrest MP, Schürmann B, Bach AP, Martin-de-Saavedra MD, et al. Reversal of dendritic phenotypes in 16p11.2 microduplication mouse model neurons by pharmacological targeting of a network hub. Proc Natl Acad Sci USA 2016;113:8520–5. https://doi.org/10.1073/pnas.1607014113.
NO National Institute of Mental Health
NO Swiss National Science Foundation
DS Docta Complutense
RD 18 abr 2025