RT Journal Article T1 Examining Association of Personality Characteristics and Neuropsychiatric Symptoms in Post-COVID Syndrome A1 Delgado Alonso, Cristina A1 Valles Salgado, María A1 Delgado Álvarez, Alfonso A1 Gómez Ruiz, Natividad A1 Yus, Miguel A1 Polidura, Carmen A1 Pérez Izquierdo, Carlos A1 Marcos Dolado, Alberto A1 Gil, María José A1 Matías-Guiu Guía, Jorge A1 Matias Guiu, Jordi A. AB Background: We aimed to evaluate personality traits in patients with post-COVID syndrome, as well as the association with neuropsychiatric symptoms present in this disorder. Methods: The Big Five Structure Inventory was administered to 93 consecutive patients with a diagnosis of post-COVID syndrome as defined by the WHO and to demographically matched controls. We also performed a comprehensive evaluation of depression, anxiety, fatigue, sleep quality, cognitive function, and olfactory function. Results: Patients with post-COVID syndrome scored lower for emotional stability, equanimity, positive mood, and self-control. Extraversion, emotional stability, and openness correlated negatively with anxiety and depression levels. Conscientiousness correlated negatively with anxiety. No statistically significant correlations were observed between personality traits and cognitive function, sleep quality, olfactory function, or fatigue. Personality scores explained 36.3% and 41% of the variance in scores on the anxiety and depression scales, respectively. Two personality profiles with lower levels of emotional stability were associated with depression and anxiety. Conclusions: Our study shows higher levels of neuroticism in patients with post-COVID syndrome. Personality traits were predictive of the presence of depression and anxiety, but not cognitive function, sleep quality, or fatigue, in the context of post-COVID syndrome. These findings may have implications for the detection of patients at risk of depression and anxiety in post-COVID syndrome, and for the development of preventive and therapeutic interventions. PB MPDI SN 2076-3425 YR 2022 FD 2022-02-14 LK https://hdl.handle.net/20.500.14352/71616 UL https://hdl.handle.net/20.500.14352/71616 LA eng NO Delgado Alonso, C., Valles Salgado, M., Delgado Álvarez, A. et al. «Examining Association of Personality Characteristics and Neuropsychiatric Symptoms in Post-COVID Syndrome». Brain Sciences, vol. 12, n.o 2, febrero de 2022, p. 265. DOI.org (Crossref), https://doi.org/10.3390/brainsci12020265. NO Instituto de Salud Carlos III/Fondo Europeo de Desarrollo Regional NO Comunidad de Madrid DS Docta Complutense RD 12 abr 2025