RT Journal Article
T1 Plasmonic nanosensors for the determination of drug effectiveness on membrane receptors
A1 Ahijado Guzmán, Rubén
A1 Menten, Julia
A1 Prasad, Janak
A1 Lambertz, Christina
A1 Rivas, German
A1 Sönnichsen, Carsten
AB We demonstrate the potential of the NanoSPR (nanoscale surface plasmon resonance sensors) method as a simple and cheap tool for the quantitative study of membrane protein–protein interactions. We use NanoSPR to determine the effectiveness of two potential drug candidates that inhibit the protein complex formation between FtsA and ZipA at initial stages of bacterial division. As the NanoSPR method relies on individual gold nanorods as sensing elements, there is no need for fluorescent labels or organic cosolvents, and it provides intrinsically high statistics. NanoSPR could become a powerful tool in drug development, drug delivery, and membrane studies.
PB ACS Publications
SN 1944-8244
YR 2017
FD 2017
LK https://hdl.handle.net/20.500.14352/93173
UL https://hdl.handle.net/20.500.14352/93173
LA eng
NO Ahijado-Guzmán, R.; Menten, J.; Prasad, J.; Lambertz, C.; Rivas, G.; Sönnichsen, C. Plasmonic Nanosensors for the Determination of Drug Effectiveness on Membrane Receptors. ACS Appl. Mater. Interfaces 2017, 9, 218-223 DOI:10.1021/acsami.6b14013.
NO Johannes Gutenberg University Mainz (Alemania)
NO Ministerio de Ciencia, Innovación y Universidades (España)
DS Docta Complutense
RD 21 jun 2026