RT Journal Article
T1 Double click macrocyclization with Sondheimer diyne of aza-dipyrrins for B–Free bioorthogonal imaging
A1 Wu, Dan
A1 Durán Sampedro, Gonzalo
A1 Fitzgerald, Sheila
A1 Garre, Massimiliano
A1 O’Shea, Donal F.
AB Sequential azide/diyne cycloadditions proved highly effective for the macrocyclization of a bis-azido aza-dipyrrin. Macrocyclic aza-dipyrrin could be produced in 30 min at rt in water with changes in fluorescence intensity and lifetimes measurable upon reaction. Live cell microscopy showed that aza-dipyrrins were suitable for confocal and STED super-resolution imaging and a bioorthogonal response to macrocyclization could be detected in cellular compartments. These results will encourage a broader examination of the sensing and imaging uses of aza-dipyrrins.
PB Royal Society of Chemistry
SN 2050-5620
YR 2023
FD 2023
LK https://hdl.handle.net/20.500.14352/114683
UL https://hdl.handle.net/20.500.14352/114683
LA eng
NO Chem. Commun., 2023,59, 1951-1954
NO European Commission
DS Docta Complutense
RD 30 dic 2025