RT Journal Article
T1 Evaluation of Elution and Mechanical Properties of High-Dose Antibiotic-Loaded Bone Cement: Comparative "In Vitro" Study of the Influence of Vancomycin and Cefazolin
A1 Paz, Eva
A1 Sanz Ruiz, Pablo
A1 Abenojar, Juana
A1 Vaquero martin, Javier
A1 Forriol, Francisco
A1 Del real, Juan Carlos
A1 Vaquero Martín, Francisco Javier
AB Use of antibiotic-loaded bone cements is one of the most effective methods for the prevention and treatment of prosthetic joint infection. However, there is still controversy about the optimal combination and doses of antibiotics that provide the maximum antimicrobial effect without compromising cement properties. In this study, vancomycin and cefazolin were added to a bone cement (Palacos R. +. G). Antibiotic release, fluid absorption, and mechanical properties were evaluated under physiological conditions. The results show that the type of antibiotic selected has an important impact on cement properties. In this study, groups with cefazolin showed much higher elution than those containing the same concentration of vancomycin. In contrast, groups with cefazolin showed a lower strength than vancomycin groups.
PB Elservier
YR 2015
FD 2015-02-28
LK https://hdl.handle.net/20.500.14352/117535
UL https://hdl.handle.net/20.500.14352/117535
LA eng
NO Paz, E., Sanz-Ruiz, P., Abenojar, J., Vaquero-Martín, J., Forriol, F., & Del Real, J. C. (2015). Evaluation of elution and mechanical properties of high-dose antibiotic-loaded bone cement: Comparative “in vitro” study of the influence of vancomycin and cefazolin. The Journal of Arthroplasty, 30(8), 1423-1429. https://doi.org/10.1016/j.arth.2015.02.040
DS Docta Complutense
RD 25 abr 2025