RT Journal Article
T1 Superior neutralizing response after first versus second SARS‐CoV‐2 infection in fully vaccinated individuals
A1 Rivas Hernández, Gonzalo
A1 Labiod Becerro, Nuria
A1 Luczkowiak, Joanna
A1 Lasala Sánchez, Fátima
A1 Rolo, Marta
A1 Mancheño Losa, Mikel
A1 Rial Crestelo, David
A1 Lora-Tamayo Morillo-Velarde, Jaime
A1 Pérez Rivilla, José Alfredo
A1 Folgueira López, María Dolores
A1 Delgado Vázquez, Rafael
AB Currently, the majority of the population has been vaccinated against COVID‐19and/or has experienced SARS‐CoV‐2 infection either before or after vaccination.The immunological response to repeated episodes of infections is not completelyclear. We measured SARS‐CoV‐2 specific neutralization titers by a pseudovirusassay after BA.1 infection and RBD‐specific immunoglobulin G (IgG), immuno-globulin A (IgA), and immunoglobulin M (IgM) in a cohort of COVID‐19uninfected and triple vaccinated individuals (breakthrough infection group,BTI) as compared with those previously infected by SARS‐CoV‐2 (reinfectiongroup, REI) who underwent identical vaccination schedule. SARS‐CoV‐2specificneutralizing response after BA.1 infection was significantly higher in the BTIgroup as compared with the REI. Furthermore, neutralization titers in REI werenot significant different from convalescent non reinfected controls. RBD‐specific IgG and IgA, but not IgM, werealso significantly higher in BTI ascompared with REI. Our results show that the first episode of SARS‐CoV‐2infection induces a significant increase inneutralizing titers in triple vaccinatedindividuals and that previous SARS‐CoV‐2 infection compromise significantly theneutralization response induced by reinfection, even by divergent SARS‐CoV‐2variants and at least up to 2 years postinfection, suggesting a fundamentallimitation in inducing effective booster through the intranasal route in previouslyinfected individuals
PB Wiley
SN 0146-6615
SN 1096-9071
YR 2023
FD 2023-11
LK https://hdl.handle.net/20.500.14352/103291
UL https://hdl.handle.net/20.500.14352/103291
LA eng
NO Rivas G, Labiod N, Luczkowiak J, Lasala F, Rolo M, Mancheño-Losa M, Rial-Crestelo D, Lora-Tamayo J, Pérez-Rivilla A, Folgueira MD, Delgado R. Superior neutralizing response after first versus second SARS-CoV-2 infection in fully vaccinated individuals. J Med Virol. 2023 Nov;95(11):e29225. doi: 10.1002/jmv.29225
NO European Commission
NO Comunidad de Madrid
NO Instituto de Salud Carlos III (España)
NO Centro de Investigación Biomédica en Red
NO Fundación Caixa‐Health Research
DS Docta Complutense
RD 9 abr 2025