RT Journal Article
T1 Memory deficits in children and adolescents with a psychotic disorder: a systematic review and meta-analysis
A1 de-la-Higuera-Gonzalez, Pilar
A1 Rodríguez Toscano, Elisa
A1 Diaz-Carracedo, Patricia
A1 Gonzalez-Urrea, Maria Juliana
A1 Padilla-Quiles, Geraldine
A1 Díaz Marsa, Marina Francisca
A1 De La-Torre Luque, Alejandro Francisco
AB Early-onset psychosis (EOP) is a severe disorder which takes place before 18 years. It entails diverse clinical and functional implications, and it may lead to critical impairments in neurocognitive functions. Although deficits in memory are well described in adult populations and they appear to be clinically related with psychosis, impairments in memory in EOP show inconsistencies between studies. This study aimed to gain insight into the relationship between EOP and memory impairments, studying the potential contribution of moderators (storage source and memory content) on the observed memory deficits. This systematic review and meta-analysis was conducted following the PRISMA-2020 guidelines. Search was conducted in English and Spanish in five databases. Case–control studies which met all requirements were selected. Overall effect size was calculated under the random-effects model and Z-based tests were used. Heterogeneity was analysed by the I2 statistic. Mixed-effects meta-regression analysis was used to study the influence of methodological quality of studies, mean age, proportion of female participants within sample, mean diagnosis, memory storage type, memory content as moderators on individual effect size variability. As a result, 32 articles were finally selected, pooling data from 2636 participants (49.29% EOP participants). Overall effect size was Hedges’ g = – 1.01, CI95 = [ – 1.35, – 0.67], p <.01, indicating lower memory performance in the EOP group in comparison to healthy controls. Diagnosis and memory storage were found as significant moderators in the memory performance variance: larger deficits were found in children with psychosis and in working memory tasks.
PB Springer
SN 0940-1334
SN 1433-8491
YR 2025
FD 2025-02-04
LK https://hdl.handle.net/20.500.14352/131267
UL https://hdl.handle.net/20.500.14352/131267
LA eng
NO ] de-la-Higuera-Gonzalez P, Rodriguez-Toscano E, Diaz-Carracedo P, Gonzalez-Urrea MJ, Padilla-Quiles G, Diaz-Marsa M, et al. Memory deficits in children and adolescents with a psychotic disorder: a systematic review and meta-analysis. Eur Arch Psychiatry Clin Neurosci 2025;275:715–32. https://doi.org/10.1007/s00406-025-01961-w.
DS Docta Complutense
RD 26 feb 2026