RT Journal Article
T1 Synthesis of Highly Efficient Multivalent Disaccharide/[60]Fullerene Nanoballs for Emergent Viruses
A1 Ramos Soriano, Javier
A1 Reina, José
A1 Illescas Martínez, Beatriz María
A1 de la Cruz, Noelia
A1 Rodríguez Pérez, Laura
A1 Lasala, Fátima
A1 Rojo, Javier
A1 Delgado Vázquez, Rafael
A1 Martín León, Nazario
AB After the last epidemic of the Zika virus (ZIKV) in Brazil that peaked in 2016, growing evidence has been demonstrated of the link between this teratogenic flavivirus and microcephaly cases. However, no vaccine or antiviral drug has been approved yet. ZIKV and Dengue viruses (DENV) entry to the host cell takes place through several receptors, including dendritic cell-specific intercellular adhesion molecule-3-grabbing nonintegrin (DC-SIGN), so that the blockade of this receptor through multivalent glycoconjugates supposes a promising biological target to inhibit the infection process. In order to get enhanced multivalency in biocompatible systems, tridecafullerenes appended with up to 360 1,2-mannobiosides have been synthesized using a strain-promoted cycloaddition of azides to alkynes (SPAAC) strategy. These systems have been tested against ZIKV and DENV infection, showing an outstanding activity in the picomolar range.
PB ACS Publications
SN 0002-7863
YR 2019
FD 2019
LK https://hdl.handle.net/20.500.14352/92902
UL https://hdl.handle.net/20.500.14352/92902
LA eng
NO Synthesis of Highly Efficient Multivalent Disaccharide/[60]Fullerene Nanoballs for Emergent Viruses Javier Ramos-Soriano, José J. Reina, Beatriz M. Illescas, Noelia de la Cruz, Laura Rodríguez-Pérez, Fátima Lasala, Javier Rojo, Rafael Delgado, and Nazario Martín Journal of the American Chemical Society 2019 141 (38), 15403-15412 DOI: 10.1021/jacs.9b08003
NO Ministerio de Economía, Comercio y Empresa (España)
NO Instituto de Salud Carlos III
NO Comisión Europea
DS Docta Complutense
RD 9 abr 2025