RT Journal Article
T1 Tear and aqueous humour cytokine profile in primary open‐angle glaucoma
A1 Burgos Blasco, Bárbara
A1 Vidal Villegas, Beatriz
A1 Sáenz Francés, Federico
A1 Morales Fernández, Laura
A1 Perucho González, Lucía
A1 García Feijoo, Julián
A1 Martínez De La Casa Fernández-Borrella, José María
AB Purpose: To evaluate the concentrations of pro‐inflammatory cytokines in tear and aqueous humour of patients with primary open‐angle glaucoma (POAG), relative to healthy controls.Method: Tear and aqueous humour samples were collected from 29 healthy controls and 27 POAG patients. Twenty‐seven inflammatory cytokines were analysed: interleukin (IL)‐1β, IL‐1ra, IL‐2, IL‐4, IL‐5, IL‐6, IL‐7, IL‐8, IL9, IL‐10, IL‐12, IL‐13, IL‐15, IL‐17, eotaxin, fibroblast growth factor (FGF) basic, granulocyte colony‐stimulating factor, granulocyte‐monocyte colony‐stimulating factor, interferon (IFN)‐γ, interferon gamma‐induced protein, monocyte chemo‐attractant protein‐1, macrophage inflammatory protein (MIP)‐1α, MIP‐1β, platelet‐derived growth factor, regulated on activation normal T cell expressed and secreted, tumour necrosis factor (TNF)‐α and vascular endothelial growth factor (VEGF).Results: In tear samples of glaucoma patients, an increase in IL‐4, IL‐12, IL‐15, FGF‐basic and VEGF was observed, as well as a decrease in MIP‐1a relative to the control group (p < 0.05). IL‐5, IL‐12, IL‐15, IFN‐γ and MIP‐1a were significantly higher in aqueous humour of glaucoma eyes (p < 0.05). A poor correlation between cytokine levels in tear and aqueous humour was observed.Conclusion: The different profiles of inflammatory marker expression of patients with POAG and healthy controls confirm the inflammatory activity of the pathology, indicating that some of them could be used as potential biomarkers of this disease.
PB John Wiley & Sons Ltd.
SN 1755-375X
YR 2020
FD 2020-02-11
LK https://hdl.handle.net/20.500.14352/6116
UL https://hdl.handle.net/20.500.14352/6116
LA eng
NO Burgos‐Blasco, B., Vidal Villegas, B., Sáenz Francés, F. et al. «Tear and Aqueous Humour Cytokine Profile in Primary Open‐angle Glaucoma». Acta Ophthalmologica, vol. 98, n.o 6, septiembre de 2020. DOI.org (Crossref), https://doi.org/10.1111/aos.14374.
NO Version of Record online: 11 February 2020; Manuscript accepted: 20 January 2020; Manuscript revised: 14 January 2020; Manuscript received: 10 September 2019
DS Docta Complutense
RD 4 abr 2025