RT Journal Article
T1 Layer-by-layer vaginal films for acyclovir controlled release to prevent genital herpes
A1 Pacheco Quito, Edisson Mauricio
A1 Bedoya Del Olmo, Luis Miguel
A1 Rubio, Juan
A1 Tamayo, Aitana
A1 Ruiz Caro, Roberto
A1 Veiga Ochoa, María Dolores
AB Genital herpes is one of the most common sexually transmitted infections worldwide. It mainly affects women, as the rate of sexual transmission from male-to-female is higher than from female-to-male. The application of vaginal antivirals drugs could reduce the prevalence of genital herpes and prevent future infections. Layer-bylayer vaginal films were prepared by the solvent evaporation method using iota-carrageenan, hydroxypropyl methylcellulose and the polymethacrylates Eudragit® RS PO and Eudragit® S100, for the controlled release of acyclovir. The films were characterized by texture analysis and Raman spectroscopy. Swelling, mucoadhesion, and drug release studies were conducted in simulated vaginal fluid. The results show that Layer-by-Layer films exhibited adequate mechanical properties. The structuring of the layer-by-layer films allowed the controlled release of acyclovir and produced a prolonged mucoadhesion residence time of up to 192 h. The films formed in layer 2 by the combination of Eudragit® RS PO and S100 showed a controlled release of acyclovir for eight days, and adequate mechanical properties. These promising formulations for the prevention of genital herpes deserve further evaluation.
PB Elsevier
SN 0378-5173
YR 2022
FD 2022-09-27
LK https://hdl.handle.net/20.500.14352/72119
UL https://hdl.handle.net/20.500.14352/72119
LA eng
NO CRUE-CSIC (Acuerdos Transformativos 2022)
NO Ministerio de Ciencia, Innovación y Universidades (España)/Fondo Europeo de Desarrollo Regional
NO Ministerio de Economía, Comercio y Empresa (España)
DS Docta Complutense
RD 19 abr 2025