RT Journal Article
T1 Analysis of the Oral Microbiome in a Patient with Cardiofaciocutaneous Syndrome and Severe Periodontal Disease: Impact of Systemic Antibiotic Therapy
A1 Muñoz Navarro, Carolina
A1 Sánchez Beltrán, María Del Carmen
A1 Arriagada Vargas, Carolina
A1 Batalla Vázquez, Pilar
A1 Diniz Freitas, Márcio
A1 Limeres Posse, Jacobo
A1 Diz Dios, Pedro
A1 García Mato, Eliane
AB An 8-year-old girl diagnosed with cardiofaciocutaneous syndrome presented to our department with gingival pain, inflammation, and bleeding. Her medical history included hypoplasia of the corpus callosum, intellectual disability, trichothiodystrophy, global developmental delay, myopia, laryngomalacia, hypothyroidism, and osteoporosis. A diagnosis was reached of “periodontitis as a direct manifestation of systemic diseases”. During 9 years of follow-up, there were exacerbation episodes with spontaneous gum bleeding, ulcers in the interdental papilla, tooth mobility, and progressive tooth loss. Some of these exacerbation episodes resolved clinically with the administration of amoxicillin and metronidazole. We therefore proposed an oral microbiome study (subgingival and saliva samples) before and after antibiotic therapy. The most abundant genera at the subgingival level before administering antibiotics were Prevotella, Streptococcus, Fusobacterium, Leptotrichia, and Aggregatibacter. Of the 94 genera sequenced, 57 were less abundant in the post-treatment state than at baseline, particularly certain Gram-negative periodontal pathogens such as Porphyromonas, Treponema, Aggregatibacter, Fusobacterium, and Campylobacter. In contrast, other genera related to oral health, such as Haemophilus, Granulicatella, and Abiotrophia, showed an increase after administering the antibiotic. In conclusion, periodontitis exacerbations as a direct manifestation of systemic disease can occasionally be controlled exclusively with systemic antibiotics, without the need for performing mechanical periodontal therapy. This clinical recovery is correlated to substantial changes in the oral microbiome, which lead to the recovery of eubiosis of the microbiota.
PB MDPI
SN 2079-6382
YR 2022
FD 2022-12-04
LK https://hdl.handle.net/20.500.14352/106778
UL https://hdl.handle.net/20.500.14352/106778
LA eng
NO Muñoz Navarro, C.; del Carmen Sánchez Beltrán, M.; Arriagada Vargas, C.; Batalla Vázquez, P.; Diniz Freitas, M.; Limeres Posse, J.; Diz Dios, P.; García Mato, E. Analysis of the Oral Microbiome in a Patient with Cardiofaciocutaneous Syndrome and Severe Periodontal Disease: Impact of Systemic Antibiotic Therapy. Antibiotics 2022, 11, 1754. https://doi.org/10.3390/antibiotics11121754
DS Docta Complutense
RD 24 abr 2025