RT Journal Article
T1 Brain functional connectivity after cognitive-bias modification and behavioral changes in abstinent alcohol-use disorder patients
A1 Martinez Maldonado, Andres
A1 Jurado Barba, Rosa
A1 Sion, Ana Mª Alexandra
A1 Dominguez Centeno, Isabel
A1 Castillo Parra, Gabriela
A1 Prieto Montalvo, Julio Ignacio
A1 Rubio Valladolid, Gabriel
AB The use of the cognitive-bias modification (CBM) method has emerged as a therapeutic complement in the treatment of alcoholism, producing changes at behavioral and brain level. Nevertheless, the impact of the CBM procedure could be improved by the memory retrieval-extinction process (REP). Different studies have demonstrated that the retrieval of drug memories before extinction training later reduced the reinstatement of drug-seeking behavior. The main aim of this work was to study the effect of the CBM procedure itself, as well as in combination with the activation of alcohol-related memories, on the brain oscillatory activity of abstinent patients with alcohol-use disorder. The study sample comprised 33 patients divided into three groups: A-CBM (alcohol-related memory activation + CBM), N-CBM (neutral memory activation + CBM) and N-INT (no-intervention) groups. A resting-state EEG was obtained before and after each protocol, along with the assessment of the automatic action tendencies. A-CBM group showed a general alpha synchronization increase after the protocol, while the other groups did not show any significant change. Besides, A-CBM group showed significant intra and inter-group differences in the automatic action tendencies after the protocol, reflected in higher avoidance bias toward appetitive, aversive and without context alcohol-related stimuli. The alpha phase synchronization increase could be the neural manifestation of the conditioning produced between the alcohol-related stimuli and the automatic avoidance response. Moreover, the activation of the alcohol-related memories favors this conditioning with those alcohol-related stimuli associated with the activated memories, because it increases their threat level for the abstinence maintenance.
PB Elsevier
YR 2020
FD 2020-08
LK https://hdl.handle.net/20.500.14352/133823
UL https://hdl.handle.net/20.500.14352/133823
LA eng
NO Martínez-Maldonado, A., Jurado-Barba, R., Sion, A., Domínguez-Centeno, I., Castillo-Parra, G., Prieto-Montalvo, J., & Rubio, G. (2020). Brain functional connectivity after cognitive-bias modification and behavioral changes in abstinent alcohol-use disorder patients. International Journal of Psychophysiology, 154, 46-58. https://doi.org/10.1016/j.ijpsycho.2019.10.004
NO Instituto de Salud Carlos III
NO Ministerio de Economía y Competitividad (España)
DS Docta Complutense
RD 21 mar 2026